التفاصيل البيبلوغرافية
| العنوان: |
HTLV-1/2 Infection in Blood Donors from a Non-Endemic Area (Catalonia, Spain) between 2008 and 2017 : A 10-Year Experience |
| المؤلفون: |
Piron, Maria, Salvador, Fernando, Caballero Requero, Estrella, Sánchez-Montalvá, Adrián, Bes, Marta, Casamitjana, Natàlia, Puig Sanz, Lluís, Molina Romero, Israel, Sauleda, Silvia, Universitat Autònoma de Barcelona |
| سنة النشر: |
2022 |
| المجموعة: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| مصطلحات موضوعية: |
HTLV-1/2, Screening, Blood donors, Leukoreduction, Transfusion, Spain |
| الوصف: |
Human T-cell lymphotropic virus type 1 and 2 (HTLV-1/2) screening is not mandatory in Spanish blood banks. In Catalonia, selective screening was introduced in 2008, followed by universal screening in 2011. We present herein a 10-year experience of HTLV testing in blood donors. HTLV-1/2 selective screening was performed using Ortho-Clinical Diagnostics HTLV-I/HTLV-II Ab-Capture ELISA between February 2008 and May 2009, then Abbott Prism HTLV-I/ HTLV-II assay until December 2010. Abbott Architect rHTLV-I/II assay was then used for HTLV-1/2 universal screening in pooled samples. INNO-LIA HTLV I/II Score (Fujirebio) and in-house HTLV-1/2 proviral DNA real-time PCR were used in reactive samples. Follow-up was offered to confirm HTLV-1/2 donors in Vall d'Hebron Hospital. Between 2008 and 2017, 51 blood donors were confirmed HTLV positive (46 HTLV-1, 4 HTLV-2 and 1 HTLV) out of 2,114,891 blood donations (1 in 41,468). Sixty-nine percent were female, median age was 40 years and most were born in Latin America (69%), followed by Europe (25%), Africa (4%) and Asia (2%). Screening of relatives and partners identified 12 additional HTLV-1 cases. Lookback studies did not show any HTLV-1/2 transmission. HTLV infections found in blood donors mirror epidemiological changes in the population of Spain. Consequently, HTLV should be considered a potential risk for recipients and calls for the design of optimal strategies to ensure transfusion safety |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Instituto de Salud Carlos III JE18/00022; Viruses; Vol. 14 (september 2022); https://ddd.uab.cat/record/266274Test; urn:10.3390/v14091975; urn:oai:ddd.uab.cat:266274; urn:pmcid:PMC9504911; urn:pmc-uid:9504911; urn:pmid:36146780; urn:oai:pubmedcentral.nih.gov:9504911; urn:oai:egreta.uab.cat:publications/dc9c49fb-9410-4278-818c-2e406c5626ae |
| الإتاحة: |
https://ddd.uab.cat/record/266274Test |
| حقوق: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.2137F535 |
| قاعدة البيانات: |
BASE |
