دورية أكاديمية
Intranasal mask for protecting the respiratory tract against viral aerosols
| العنوان: | Intranasal mask for protecting the respiratory tract against viral aerosols |
|---|---|
| المؤلفون: | Hu, Xiaoming, Wang, Shuang, Fu, Shaotong, Qin, Meng, Lyu, Chengliang, Ding, Zhaowen, Wang, Yan, Wang, Yishu, Wang, Dongshu, Zhu, Li, Jiang, Tao, Sun, Jing, Ding, Hui, Wu, Jie, Chang, Lingqian, Cui, Yimin, Pang, Xiaocong, Wang, Youchun, Huang, Weijin, Yang, Peidong, Wang, Limin, Ma, Guanghui, Wei, Wei |
| المصدر: | Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary |
| الوصف: | The spread of many infectious diseases relies on aerosol transmission to the respiratory tract. Here we design an intranasal mask comprising a positively-charged thermosensitive hydrogel and cell-derived micro-sized vesicles with a specific viral receptor. We show that the positively charged hydrogel intercepts negatively charged viral aerosols, while the viral receptor on vesicles mediates the entrapment of viruses for inactivation. We demonstrate that when displaying matched viral receptors, the intranasal masks protect the nasal cavity and lung of mice from either severe acute respiratory syndrome coronavirus 2 or influenza A virus. With computerized tomography images of human nasal cavity, we further conduct computational fluid dynamics simulation and three-dimensional printing of an anatomically accurate human nasal cavity, which is connected to human lung organoids to generate a human respiratory tract model. Both simulative and experimental results support the suitability of intranasal masks in humans, as the likelihood of viral respiratory infections induced by different variant strains is dramatically reduced. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-023-44134-w |
| الإتاحة: | https://doi.org/10.1038/s41467-023-44134-wTest https://www.nature.com/articles/s41467-023-44134-w.pdfTest https://www.nature.com/articles/s41467-023-44134-wTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.2136FE65 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-023-44134-w |
|---|