كتاب
Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus
| العنوان: | Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus |
|---|---|
| المؤلفون: | Yvonne Imielski, Jens C. Schwamborn, Patrick Lüningschrör, Peter Heimann, Magdalena Holzberg, Hendrikje Werner, Oliver Leske, Andreas W. Püschel, Sylvie Memet, Rolf Heumann, Alain Israel, Christian Kaltschmidt, Barbara Kaltschmidt |
| المصدر: | Nature Precedings |
| سنة النشر: | 2011 |
| المجموعة: | Nature Precedings |
| مصطلحات موضوعية: | Developmental Biology, Genetics & Genomics, Molecular Cell Biology, Neuroscience |
| الوصف: | Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus, which could be regenerated by adult neurogenesis. Here we show that genetic ablation of NF-κB resulted in severe defects in the neurogenic region (dentate gyrus) of the hippocampus. Despite increased stem cell proliferation, axogenesis, synaptogenesis and neuroprotection were hampered, leading to disruption of the mossy fiber pathway and to atrophy of the dentate gyrus during aging. Here, NF-κB controls the transcription of FOXO1 and PKA, regulating axogenesis. Structural defects culminated in behavioral impairments in pattern separation. Re-activation of NF-κB resulted in integration of newborn neurons, finally to regeneration of the dentate gyrus, accompanied by a complete recovery of structural and behavioral defects. These data identify NF-κB as a crucial regulator of dentate gyrus tissue homeostasis suggesting NF-κB to be a therapeutic target for treating cognitive and mood disorders. |
| نوع الوثيقة: | manuscript |
| اللغة: | unknown |
| العلاقة: | http://precedings.nature.com/documents/6096/version/1Test; oai:nature.com:10101/npre.2011.6096.1; http://hdl.handle.net/10101/npre.2011.6096.1Test |
| الإتاحة: | http://precedings.nature.com/documents/6096/version/1Test http://hdl.handle.net/10101/npre.2011.6096.1Test |
| حقوق: | Creative Commons Attribution 3.0 License |
| رقم الانضمام: | edsbas.2135F387 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |