دورية أكاديمية
Results from the European Union MAPEC_LIFE cohort study on air pollution and chromosomal damage in children: are public health policies sufficiently protective?
| العنوان: | Results from the European Union MAPEC_LIFE cohort study on air pollution and chromosomal damage in children: are public health policies sufficiently protective? |
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| المؤلفون: | Ceretti, Elisabetta, Donato, Francesco, Zani, Claudia, Villarini, Milena, Verani, Marco, De Donno, Antonella, Bonetta, Sara, Feretti, Donatella, Carducci, Annalaura, Idolo, Adele, Carraro, Elisabetta, Covolo, Loredana, Moretti, Massimo, Palomba, Giacomo, Grassi, Tiziana, Bonetti, Alberto, Bonizzoni, Silvia, Biggeri, Annibale, Gelatti, Umberto, Festa A., Viola G. C. V., Zerbini I., Fatigoni C., Levorato S., Monarca S., Salvatori T., Vannini S., Donzelli G., Bagordo F., De Giorgi M., Guido M., Panico A., Serio F., Tumolo M. R., Bonetta S., Gea M., Gilli G., Pignata C., Schilirò T., Romanazzi V., Furia C., Bruni B., Casini B. |
| المساهمون: | Ceretti, Elisabetta, Donato, Francesco, Zani, Claudia, Villarini, Milena, Verani, Marco, De Donno, Antonella, Bonetta, Sara, Feretti, Donatella, Carducci, Annalaura, Idolo, Adele, Carraro, Elisabetta, Covolo, Loredana, Moretti, Massimo, Palomba, Giacomo, Grassi, Tiziana, Bonetti, Alberto, Bonizzoni, Silvia, Biggeri, Annibale, Gelatti, Umberto, Festa, A., Viola, G. C. V., Zerbini, I., Fatigoni, C., Levorato, S., Monarca, S., Salvatori, T., Vannini, S., Donzelli, G., Bagordo, F., De Giorgi, M., Guido, M., Panico, A., Serio, F., Tumolo, M. R., Bonetta, S., Gea, M., Gilli, G., Pignata, C., Schilirò, T., Romanazzi, V., Furia, C., Bruni, B., Casini, B. |
| سنة النشر: | 2020 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | Chromosomal damage, Biomarkers of early effect, Children, Air pollution exposure, Air quality policy |
| الوصف: | Background Children are at high risk of suffering health consequences of air pollution and childhood exposure can increase the risk of developing chronic diseases in adulthood. This study, part of the MAPEC_LIFE project (LIFE12 ENV/IT/000614), aimed to investigate the associations between exposure to urban air pollutants and micronucleus (MN) frequency, as a biomarker of chromosomal damage, in buccal cells of children for supporting implementation and updating of environmental policy and legislation. Methods This prospective epidemiological cohort study was carried out on 6- to 8-year-old children living in five Italian towns with different levels and features of air pollution. Exfoliated buccal cells of the children were sampled twice, in winter and spring, obtaining 2139 biological samples for genotoxicological investigation. Micronucleus (MN) frequency was investigated in buccal cells of children and its association with air pollution exposure was assessed applying multiple Poisson regression mixed models, including socio-demographic and lifestyle factors as confounders. We also dichotomize air pollutants' concentration according to the EU Ambient Air Quality Directives and WHO Air Quality Guidelines in all Poisson regression models to assess their risk predictive capacity. Results Positive and statistically significant associations were found between MN frequency and PM10, PM2.5, benzene, SO2 and ozone. The increment of the risk of having MN in buccal cells for each mu g/m(3) increase of pollutant concentration was maximum for benzene (18.9%, 95% CIs 2.2-38.4%) and modest for the other pollutants (between 0.2 and 1.4%). An increased risk (between 17.9% and 59.8%) was found also for exposure to PM10, benzene and benzo(a)pyrene levels higher than the threshold limits. Conclusions Some air pollutants are able to induce chromosomal damage in buccal cells of children even at concentrations below present EU/WHO limits. This type of biological effects may be indicative of the environmental pressure which ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000554711100001; volume:32; issue:74; firstpage:1; lastpage:11; numberofpages:11; journal:ENVIRONMENTAL SCIENCES EUROPE; http://hdl.handle.net/11568/1041660Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85084298634 |
| DOI: | 10.1186/s12302-020-00352-3 |
| الإتاحة: | https://doi.org/10.1186/s12302-020-00352-3Test http://hdl.handle.net/11568/1041660Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.20BD2C19 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12302-020-00352-3 |
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