التفاصيل البيبلوغرافية
| العنوان: |
A high-fat and fructose diet in dogs mirrors insulin resistance and β-cell dysfunction characteristic of impaired glucose tolerance in humans |
| المؤلفون: |
Gregory, Justin M., Kraft, Guillaume, Dalla Man, Chiara, Slaughter, James C., Scott, Melanie F., Hastings, Jon R., Edgerton, Dale S., Moore, Mary C., Cherrington, Alan D. |
| المساهمون: |
Onwukwe, Chikezie Hart, National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, Vanderbilt Diabetes Research and Training Center, JDRF Career Development Award, Fractyl Health and Metavention |
| المصدر: |
PLOS ONE ; volume 18, issue 12, page e0296400 ; ISSN 1932-6203 |
| بيانات النشر: |
Public Library of Science (PLoS) |
| سنة النشر: |
2023 |
| المجموعة: |
PLOS Publications (via CrossRef) |
| الوصف: |
This study examined the impact of a hypercaloric high-fat high-fructose diet (HFFD) in dogs as a potential model for human impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). The HFFD not only led to weight gain but also triggered metabolic alterations akin to the precursors of human T2DM, notably insulin resistance and β-cell dysfunction. Following the HFFD intervention, the dogs exhibited a 50% decrease in insulin sensitivity within the first four weeks, paralleling observations in the progression from normal to IGT in humans. Calculations of the insulinogenic index using both insulin and C-peptide measurements during oral glucose tolerance tests revealed a significant and sustained decrease in early-phase insulin release, with partial compensation in the later phase, predominantly stemming from reduced hepatic insulin clearance. In addition, the Disposition Index, representing the β-cell’s capacity to compensate for diminished insulin sensitivity, fell dramatically. These results confirm that a HFFD can instigate metabolic changes in dogs akin to the early stages of progression to T2DM in humans. The study underscores the potential of using dogs subjected to a HFFD as a model organism for studying human IGT and T2DM. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1371/journal.pone.0296400 |
| الإتاحة: |
https://doi.org/10.1371/journal.pone.0296400Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.20A2235E |
| قاعدة البيانات: |
BASE |
