دورية أكاديمية
Omadacycline Efficacy against Streptococcus Agalactiae Isolated in China: Correlation between Resistance and Virulence Gene and Biofilm Formation
| العنوان: | Omadacycline Efficacy against Streptococcus Agalactiae Isolated in China: Correlation between Resistance and Virulence Gene and Biofilm Formation |
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| المؤلفون: | Guiqiu Li, Ying Wei, Yan Guo, Hui Gong, Jie Lian, Guangjian Xu, Bing Bai, Zhijian Yu, Qiwen Deng |
| المصدر: | Computational Intelligence and Neuroscience, Vol 2022 (2022) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Computer applications to medicine. Medical informatics, R858-859.7, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | This study aimed to evaluate the activity, resistance, clonality of MIC distribution, and the correlation between virulence and resistance genes and biofilm formation of omadacycline (OMC) in clinics for Streptococcus agalactiae isolates from China. 162 isolates were collected retrospectively in China. The S. agalactiae were collected from the body’s cervical secretions, wound secretions, ear swabs, secretions, semen, venous blood, cerebrospinal fluid, pee, etc. The MIC of OMC against S. agalactiae was determined by broth microdilution. The inhibition zone diameters of OMC and other common antibiotics were measured using filter paper. D-test was performed to determine the phenotype of cross resistance between erythromycin and clindamycin. In Multilocus sequence typing (MLST), some commonly-detected resistance genes and virulence gene of these S. agalactiae isolates were investigated using polymerase chain reaction (PCR). Biofilms were detected by crystal violet staining. Our data demonstrated the correalation of the biofilm formation and OMA antimicrobial susceptibility of S.agalactiae clinical isolates with the carrier of virulence gene scpB. Conclusively, OMC exhibits the robust antimcirobial activity against clinical S. agalactiae isolates from China compared with DOX or MIN, and the carrier of the virulence gene scpB might correlate with the biofilm formation in OMC-resistant S. agalactiae. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1687-5273 |
| العلاقة: | http://dx.doi.org/10.1155/2022/7636983Test; https://doaj.org/toc/1687-5273Test; https://doaj.org/article/358e48fed6eb4fd1a5a53286e25d94deTest |
| DOI: | 10.1155/2022/7636983 |
| الإتاحة: | https://doi.org/10.1155/2022/7636983Test https://doaj.org/article/358e48fed6eb4fd1a5a53286e25d94deTest |
| رقم الانضمام: | edsbas.209C0E5D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16875273 |
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| DOI: | 10.1155/2022/7636983 |