دورية أكاديمية
Adjuvant trastuzumab emtansine in HER2-positive breast cancer patients with HER2-negative residual invasive disease in KATHERINE
| العنوان: | Adjuvant trastuzumab emtansine in HER2-positive breast cancer patients with HER2-negative residual invasive disease in KATHERINE |
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| المؤلفون: | Loibl, Sibylle, Huang, Chiun-Sheng, Mano, Max S., Mamounas, Eleftherios P., Geyer, Charles E., Untch, Michael, Thery, Jean-Christophe, Schwaner, Ingo, Limentani, Steven, Loman, Niklas, Lübbe, Kristina, Chang, Jenny C., Hatschek, Thomas, Tesarowski, David, Song, Chunyan, Lysbet de Haas, Sanne, Boulet, Thomas, Lambertini, Chiara, Wolmark, Norman |
| المساهمون: | Roche |
| المصدر: | npj Breast Cancer ; volume 8, issue 1 ; ISSN 2374-4677 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmacology (medical), Radiology, Nuclear Medicine and imaging, Oncology |
| الوصف: | Following chemotherapy and human epidermal growth factor 2 (HER2)-targeted neoadjuvant therapy for HER2-positive early breast cancer, residual invasive breast cancer at surgery may be HER2-negative on retesting in some patients. We evaluated outcomes with T-DM1 and trastuzumab in patients randomized in the phase III KATHERINE trial based on HER2-positive central testing of the pre-treatment core biopsy with HER2-negative central testing on their corresponding surgical specimen after neoadjuvant treatment. In the 70/845 (8.3%) patients with HER2-negative residual disease on retesting at surgery, there were 11 IDFS events in the 42 trastuzumab-treated patients (26.2%) and none in the 28 T-DM1-treated patients, suggesting that T-DM1 should not be withheld in this patient population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41523-022-00477-z |
| الإتاحة: | https://doi.org/10.1038/s41523-022-00477-zTest https://www.nature.com/articles/s41523-022-00477-z.pdfTest https://www.nature.com/articles/s41523-022-00477-zTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.2086885 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41523-022-00477-z |
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