دورية أكاديمية
Impact of gender on relative rates of cardiovascular events in patients with diabetes
| العنوان: | Impact of gender on relative rates of cardiovascular events in patients with diabetes |
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| المؤلفون: | Angoulvant, Denis, Ducluzeau, Pierre-Henri, Renoult-Pierre, Peggy, Fauchier, Grégoire, Herbert, Julien, Semaan, Carl, Bodin, Alexandre, Bisson, Arnaud, Fauchier, Laurent |
| المساهمون: | Transplantation, Immunologie, Inflammation Tours (T2i), Université de Tours (UT), Physiologie de la reproduction et des comportements Nouzilly (PRC), Institut Français du Cheval et de l'Equitation Saumur (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Bretonneau |
| المصدر: | ISSN: 2398-9238 ; Endocrinology, Diabetes & Metabolism ; https://hal.inrae.fr/hal-03468079Test ; Endocrinology, Diabetes & Metabolism, 2021, 47 (5), pp.1-8. ⟨10.1016/j.diabet.2021.101226⟩. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Université François-Rabelais de Tours: HAL |
| مصطلحات موضوعية: | Cardiovascular disease, Diabetes, Heart failure, Myocardial infarction, Gender difference, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Aim. - To investigate whether diabetes confers higher relative risks of cardiovascular events in women compared with men using contemporary data and also whether such gender-differences are dependent on age.Methods. - All patients discharged from French hospitals in 2013 with at least 5 years of follow-up and no history of major adverse cardiovascular events including heart failure (MACE-HF; heart failure, myocardial infarction, ischaemic stroke, cardiovascular death) were identified and categorized by diabetes status. Overall and age-stratified incidence rates, hazard ratios (HRs) and women-to-men ratios (WMRs) for MACE-HF leading to hospitalization were also calculated. Adjustments were then made for age and baseline characteristics according to cardiovascular risk factors and non-cardiovascular comorbidities.Results. - The study included 2,953,816 subjects, among whom 349,928 (11.9%) had diabetes. Of those with diabetes, the absolute rate of MACE-HF was higher in men than in women (96 vs 66 per 1000 person-years); corresponding absolute rates in men and women without diabetes were 44 vs 27 per 1000 person-years. Comparing those with and without diabetes, women had a higher unadjusted HR of MACE-HF (2.45, 95% CI: 2.42-2.47) than men (2.15, 95% CI: 2.14-2.17), with an adjusted WMR of 1.13 (95% CI: 1.12-1.15). HRs of MACE-HF related to diabetes were highest in women aged around 45 years and in the youngest men and decreased with advancing age in both these groups. However, HRs were higher in women of all ages > 40 years. After adjustment, this effect was more apparent for myocardial infarction (adjusted WMR: 1.43, 95% CI: 1.38-1.48) than for either ischaemic stroke (adjusted WMR: 1.10, 95% CI: 1.07-1.14) or heart failure (adjusted WMR: 1.13, 95% CI: 1.11-1.14).Conclusion. - Although men have higher absolute risks of cardiovascular complications, the relative risks of cardiovascular complications associated with diabetes are higher in women than in men. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03468079; https://hal.inrae.fr/hal-03468079Test; https://hal.inrae.fr/hal-03468079/documentTest; https://hal.inrae.fr/hal-03468079/file/S1262363621000045.pdfTest; PII: S1262-3636(21)00004-5; WOS: 000713877100006 |
| DOI: | 10.1016/j.diabet.2021.101226 |
| الإتاحة: | https://doi.org/10.1016/j.diabet.2021.101226Test https://hal.inrae.fr/hal-03468079Test https://hal.inrae.fr/hal-03468079/documentTest https://hal.inrae.fr/hal-03468079/file/S1262363621000045.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-ncTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.205BFCB6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.diabet.2021.101226 |
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