دورية أكاديمية
Mechanisms by which autophagy regulates memory capacity in ageing
| العنوان: | Mechanisms by which autophagy regulates memory capacity in ageing |
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| المؤلفون: | De Risi M., Torromino G., Tufano M., Moriceau S., Pignataro A., Rivagorda M., Carrano N., Middei S., Settembre C., Ammassari-Teule M., Gardoni F., Mele A., Oury F., De Leonibus E. |
| المساهمون: | M. De Risi, G. Torromino, M. Tufano, S. Moriceau, A. Pignataro, M. Rivagorda, N. Carrano, S. Middei, C. Settembre, M. Ammassari-Teule, F. Gardoni, A. Mele, F. Oury, E. De Leonibus |
| بيانات النشر: | Wiley Blackwell Publishing |
| سنة النشر: | 2020 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | ageing, alpha-synuclein, amyloid fibril, autophagy, GluA1, mild cognitive impairment, Spermidine, Settore BIO/14 - Farmacologia |
| الوصف: | Autophagy agonists have been proposed to slow down neurodegeneration. Spermidine, a polyamine that acts as an autophagy agonist, is currently under clinical trial for the treatment of age-related memory decline. How Spermidine and other autophagy agonists regulate memory and synaptic plasticity is under investigation. We set up a novel mouse model of mild cognitive impairment (MCI), in which middle-aged (12-month-old) mice exhibit impaired memory capacity, lysosomes engulfed with amyloid fibrils (β-amyloid and α-synuclein) and impaired task-induced GluA1 hippocampal post-translation modifications. Subchronic treatment with Spermidine as well as the autophagy agonist TAT-Beclin 1 rescued memory capacity and GluA1 post-translational modifications by favouring the autophagy/lysosomal-mediated degradation of amyloid fibrils. These findings provide new mechanistic evidence on the therapeutic relevance of autophagy enhancers which, by improving the degradation of misfolded proteins, slow down age-related memory decline. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32729663; info:eu-repo/semantics/altIdentifier/wos/WOS:000553553200001; volume:19; issue:9; numberofpages:15; journal:AGING CELL; http://hdl.handle.net/2434/787385Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85088790610 |
| DOI: | 10.1111/acel.13189 |
| الإتاحة: | https://doi.org/10.1111/acel.13189Test http://hdl.handle.net/2434/787385Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1FE52662 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/acel.13189 |
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