التفاصيل البيبلوغرافية
| العنوان: |
The Activation Status of Neuroantigen-specific T Cells in the Target Organ Determines the Clinical Outcome |
| المؤلفون: |
Of Autoimmune Encephalomyelitis, Naoto Kawakami, Silke Lassmann, Zhaoxia Li, Francesca Odoardi, Thomas Ritter, Tjalf Ziemssen, Wolfgang E. F. Klinkert, Joachim W. Ellwart, Monika Bradl, Kimberly Krivacic, Hans Lassmann, Richard M. Ransohoff, Hans-dieter Volk, Hartmut Wekerle, Christopher Linington, Er Flügel |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://jem.rupress.org/content/199/2/185.full.pdfTest. |
| سنة النشر: |
2004 |
| المجموعة: |
CiteSeerX |
| الوصف: |
The clinical picture of experimental autoimmune encephalomyelitis (EAE) is critically dependent on the nature of the target autoantigen and the genetic background of the experimental animals. Potentially lethal EAE is mediated by myelin basic protein (MBP)–specific T cells in Lewis rats, whereas transfer of S100�- or myelin oligodendrocyte glycoprotein (MOG)–specific T cells causes intense inflammatory response in the central nervous system (CNS) with minimal disease. However, in Dark Agouti rats, the pathogenicity of MOG-specific T cells resembles the one of MBP-specific T cells in the Lewis rat. Using retrovirally transduced green fluorescent T cells, we now report that differential disease activity reflects different levels of autoreactive effector T cell activation in their target tissue. Irrespective of their pathogenicity, the migratory activity, gene expression patterns, and immigration of green fluorescent protein � T cells into the CNS were similar. However, exclusively highly pathogenic T cells were significantly reactivated within the CNS. Without local effector T cell activation, production of monocyte chemoattractants was insufficient to initiate and propagate a full inflammatory response. Low-level reactivation of weakly pathogenic T cells was not due to anergy because these cells could be activated by |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.6640Test; http://jem.rupress.org/content/199/2/185.full.pdfTest |
| الإتاحة: |
http://jem.rupress.org/content/199/2/185.full.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.1F8D9A2B |
| قاعدة البيانات: |
BASE |
