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An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction

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العنوان: An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction
المؤلفون: Sando, Steven R, Bhatla, Nikhil, Lee, Eugene LQ, Horvitz, H Robert
المصدر: eLife
بيانات النشر: eLife Sciences Publications, Ltd
سنة النشر: 2021
المجموعة: DSpace@MIT (Massachusetts Institute of Technology)
الوصف: Neural control of muscle function is fundamental to animal behavior. Many muscles can generate multiple distinct behaviors. Nonetheless, individual muscle cells are generally regarded as the smallest units of motor control. We report that muscle cells can alter behavior by contracting subcellularly. We previously discovered that noxious tastes reverse the net flow of particles through the C. elegans pharynx, a neuromuscular pump, resulting in spitting. We now show that spitting results from the subcellular contraction of the anterior region of the pm3 muscle cell. Subcellularly localized calcium increases accompany this contraction. Spitting is controlled by an ‘hourglass’ circuit motif: parallel neural pathways converge onto a single motor neuron that differentially controls multiple muscles and the critical subcellular muscle compartment. We conclude that subcellular muscle units enable modulatory motor control and propose that subcellular muscle contraction is a fundamental mechanism by which neurons can reshape behavior.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/octet-stream
اللغة: English
تدمد: 2050-084X
العلاقة: http://dx.doi.org/10.7554/elife.59341Test; eLife; https://hdl.handle.net/1721.1/135345.2Test
الإتاحة: https://doi.org/10.7554/elife.59341Test
https://hdl.handle.net/1721.1/135345.2Test
حقوق: Creative Commons Attribution 4.0 International license ; https://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام: edsbas.1F80F786
قاعدة البيانات: BASE
الوصف
تدمد:2050084X