دورية أكاديمية
Modeling regulation of vascular tone following muscle contraction: Model development, validation and global sensitivity analysis
| العنوان: | Modeling regulation of vascular tone following muscle contraction: Model development, validation and global sensitivity analysis |
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| المؤلفون: | Keijsers, J. M. T., Leguy, C. A. D., Narracott, A. J., Rittweger, J., van de Vosse, F. N., Huberts, W. |
| المصدر: | Keijsers , J M T , Leguy , C A D , Narracott , A J , Rittweger , J , van de Vosse , F N & Huberts , W 2018 , ' Modeling regulation of vascular tone following muscle contraction: Model development, validation and global sensitivity analysis ' , Journal of Computational Science , vol. 24 , pp. 143-159 . https://doi.org/10.1016/j.jocs.2017.04.007Test |
| سنة النشر: | 2018 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | Regulation of vascular tone, Metabolic regulation, Myogenic regulation, Baroreflex, 1D pulse wave propagation, IMMEDIATE EXERCISE HYPEREMIA, WAVE-PROPAGATION MODEL, MATHEMATICAL-MODEL, BLOOD-FLOW, INTRACRANIAL-PRESSURE, RAPID VASODILATION, AUTOREGULATION, CIRCULATION, DYNAMICS, HUMANS |
| الوصف: | In this study the regulation of vascular tone inducing the blood flow increase at the onset of exercise is examined. Therefore, our calf circulation model was extended with a regulation model to simulate changes in vascular tone depending on myogenic, metabolic and baroreflex regulation. The simulated blood flow corresponded to the in vivo response and it was concluded that metabolic activation caused the flow increase shortly after muscle contraction. Secondly, the change in baseline flow upon tilt was a result of myogenic and baroreflex activation. Based on a sensitivity analysis the myogenic gain was identified as most important parameter. (C) 2017 Elsevier B.V. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.jocs.2017.04.007 |
| الإتاحة: | https://doi.org/10.1016/j.jocs.2017.04.007Test https://cris.maastrichtuniversity.nl/en/publications/6f88918c-0ba7-45d0-9172-c8b6a460e8f3Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.1F6117FC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jocs.2017.04.007 |
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