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Age and sex associate with outcome in older AML and high risk MDS patients treated with 10-day decitabine.

التفاصيل البيبلوغرافية
العنوان: Age and sex associate with outcome in older AML and high risk MDS patients treated with 10-day decitabine.
المؤلفون: Hilberink, J.R., van Zeventer, I.A., Chitu, D.A., Pabst, T., Klein, S.K., Stussi, G., Griskevicius, L., Valk, PJM, Cloos, J., van de Loosdrecht, A.A., Breems, D., van Lammeren-Venema, D., Boersma, R., Jongen-Lavrencic, M., Fehr, M., Hoogendoorn, M., Manz, M.G., Söhne, M., van Marwijk Kooy, R., Deeren, D., van der Poel, MWM, Legdeur, M.C., Tick, L., Chalandon, Y., Ammatuna, E., Blum, S., Löwenberg, B., Ossenkoppele, G.J., Huls, G.
المساهمون: Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON), Swiss Group for Clinical Cancer Research (SAKK), Chitu, D.A., Klein, S.K., Griskevicius, L., Valk, PJM, Cloos, J., van de Loosdrecht, A.A., Breems, D., van Lammeren-Venema, D., Boersma, R., Jongen-Lavrencic, M., Söhne, M., van Marwijk Kooy, R., Deeren, D., van der Poel, MWM, Legdeur, M.C., Tick, L., Ammatuna, E., Löwenberg, B., Ossenkoppele, G.J., Huls, G., Pabst, T., Stussi, G., Fehr, M., Manz, M.G., Chalandon, Y., Blum, S.
المصدر: Blood cancer journal, vol. 13, no. 1, pp. 93
سنة النشر: 2023
المجموعة: Université de Lausanne (UNIL): Serval - Serveur académique lausannois
مصطلحات موضوعية: Humans, Male, Female, Aged, Decitabine/therapeutic use, Myelodysplastic Syndromes/genetics, Leukemia, Myeloid, Acute/genetics, Mutation, Treatment Outcome
الوصف: Treatment choice according to the individual conditions remains challenging, particularly in older patients with acute myeloid leukemia (AML) and high risk myelodysplastic syndrome (MDS). The impact of performance status, comorbidities, and physical functioning on survival is not well defined for patients treated with hypomethylating agents. Here we describe the impact of performance status (14% ECOG performance status 2), comorbidity (40% HCT-comorbidity index ≥ 2), and physical functioning (41% short physical performance battery < 9 and 17% ADL index < 6) on overall survival (OS) in 115 older patients (age ≥ 66 years) treated on a clinical trial with a 10-day decitabine schedule. None of the patient-related variables showed a significant association with OS. Multivariable analysis revealed that age > 76 years was significantly associated with reduced OS (HR 1.58; p = 0.043) and female sex was associated with superior OS (HR 0.62; p = 0.06). We further compared the genetic profiles of these subgroups. This revealed comparable mutational profiles in patients younger and older than 76 years, but, interestingly, revealed significantly more prevalent mutated ASXL1, STAG2, and U2AF1 in male compared to female patients. In this cohort of older patients treated with decitabine age and sex, but not comorbidities, physical functioning or cytogenetic risk were associated with overall survival.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 2044-5385
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37336890; info:eu-repo/semantics/altIdentifier/eissn/2044-5385; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4F3DD7E2D5288; https://serval.unil.ch/notice/serval:BIB_4F3DD7E2D528Test; urn:issn:2044-5385; https://serval.unil.ch/resource/serval:BIB_4F3DD7E2D528.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4F3DD7E2D5288Test
DOI: 10.1038/s41408-023-00850-6
الإتاحة: https://doi.org/10.1038/s41408-023-00850-6Test
https://serval.unil.ch/notice/serval:BIB_4F3DD7E2D528Test
https://serval.unil.ch/resource/serval:BIB_4F3DD7E2D528.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4F3DD7E2D5288Test
حقوق: info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام: edsbas.1F2A46D9
قاعدة البيانات: BASE
الوصف
تدمد:20445385
DOI:10.1038/s41408-023-00850-6