دورية أكاديمية
Event-related potentials and cognition in Parkinson's disease: An integrative review
| العنوان: | Event-related potentials and cognition in Parkinson's disease: An integrative review |
|---|---|
| المؤلفون: | Seer, C, Lange, F, Georgiev, D, Jahanshahi, M, Kopp, B |
| المصدر: | Neuroscience & Biobehavioral Reviews , 71 pp. 691-714. (2016) |
| بيانات النشر: | PERGAMON-ELSEVIER SCIENCE LTD |
| سنة النشر: | 2016 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Behavioral Sciences, Neurosciences, Neurosciences & Neurology, Parkinson's disease, Cognition, Dementia, Executive function, Basal ganglia, Dopamine, Event-related potentials (ERPs), P3, P3a, P3b, MMN, NoGo-P3, N2, N-e/ERN, PROGRESSIVE SUPRANUCLEAR PALSY, MULTIPLE SYSTEM ATROPHY, VISUAL WORKING-MEMORY, AMYOTROPHIC-LATERAL-SCLEROSIS, AUDITORY SELECTIVE ATTENTION, MOVEMENT-RELATED POTENTIALS, FRONTAL-LOBE DYSFUNCTION, ERROR-RELATED NEGATIVITY, NON-CAUCASIAN PATIENTS, CHOICE-REACTION TASKS |
| الوصف: | Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD), but the nature of cognitive changes varies considerably between individuals. According to the dual-syndrome hypothesis, one cluster of patients is characterized by deficits in executive function that may be related to fronto-striatal dysfunction. Other patients primarily show non-frontal cognitive impairments that progress rapidly to PD dementia (PDD). We provide a comprehensive review of event-related potential (ERP) studies to identify ERP measures substantiating the heterogeneity of cognitive impairment in PD. Our review revealed evidence for P3b and mismatch-negativity alterations in PDD, but not in non-demented PD, indicating that alterations of these ERPs constitute electrophysiological markers for PDD. In contrast, ERP correlates of executive functions, such as NoGo-P3, N2, and error(-related) negativity (Ne/ERN), appear to be attenuated in non-demented PD patients in a dopamine-dependent manner. Hence, ERP measures confirm and yield distinct electrophysiological markers for the heterogeneity of cognitive impairment in PD. We discuss limitations and open questions of the ERP approach and provide directions and predictions for future ERP research. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/1511980/1/Jahanshahi_ACCEPTED_Seer,%20Lange%20et%20al.%20%28in%20press%29%20Neurosci%20Biobehav%20Rev_afterProofreading20160906.pdfTest; https://discovery.ucl.ac.uk/id/eprint/1511980Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/1511980/1/Jahanshahi_ACCEPTED_Seer,%20Lange%20et%20al.%20%28in%20press%29%20Neurosci%20Biobehav%20Rev_afterProofreading20160906.pdfTest https://discovery.ucl.ac.uk/id/eprint/1511980Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.1E3DBB8F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |