التفاصيل البيبلوغرافية
| العنوان: |
Epiberberine suppresses the metastasis of head and neck squamous cell carcinoma cells by regulating the MMP‐13 and JNK pathway |
| المؤلفون: |
Ho, Hsin‐Yu, Chen, Mu‐Kuan, Lin, Chia‐Chieh, Lo, Yu‐Sheng, Chuang, Yi‐Ching, Hsieh, Ming‐Ju |
| المساهمون: |
National Science Council, Changhua Christian Hospital |
| المصدر: |
Journal of Cellular and Molecular Medicine ; volume 27, issue 23, page 3796-3804 ; ISSN 1582-1838 1582-4934 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2023 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Head and neck squamous cell carcinoma (HNSCC) is one of the most common histological types of head and neck cancer. Epiberberine is a potent antitumour agent for several types of cancer. This study is aimed at investigating the regulatory and molecular mechanism of epiberberine on HNSSC cell metastasis. The results showed that epiberberine inhibited the motility of Ca9‐22 and FaDu cell lines at nontoxicity doses. Moreover, the epithelial‐mesenchymal transition (EMT)‐related proteins, vimentin, snail and slug, were found suppressing after epiberberine treatments. In addition, the JNK signalling cascade and the metalloproteinase 13 (MMP‐13) expression were also found downregulated by epiberberine. In conclusion, the present study demonstrates that epiberberine suppresses cell migration and invasion by regulating the JNK pathway and MMP‐13. These results suggest that epiberberine could be a potential antimetastatic agent in HNSCC cells. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/jcmm.17954 |
| الإتاحة: |
https://doi.org/10.1111/jcmm.17954Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.1E34596F |
| قاعدة البيانات: |
BASE |
