التفاصيل البيبلوغرافية
| العنوان: |
Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment |
| المؤلفون: |
Ruan, Ruiwen, Li, Li, Li, Xuan, Huang, Chunye, Zhang, Zhanmin, Zhong, Hongguang, Zeng, Shaocheng, Shi, Qianqian, Xia, Yang, Zeng, Qinru, Wen, Qin, Chen, Jingyi, Dai, Xiaofeng, Xiong, Jianping, Xiang, Xiaojun, Lei, Wan, Deng, Jun |
| المساهمون: |
Natural Science Foundation of Jiangxi Province, Government of Jiangxi Province, Jiangxi Provincial Department of Science and Technology, Foundation of Jiangxi Educational Commission, National Natural Science Foundation of China, Youth Science Foundation of Jiangxi Province |
| المصدر: |
Molecular Cancer ; volume 22, issue 1 ; ISSN 1476-4598 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Cancer Research, Oncology, Molecular Medicine |
| الوصف: |
Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) play a crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving tumorigenesis. Therefore, many studies have targeted FGF/FGFR signaling for cancer therapy and several FGFR inhibitors have promising results in different tumors but treatment efficiency may still be improved. The clinical use of immune checkpoint blockade (ICB) has resulted in sustained remission for patients. Main Although there is limited data linking FGFR inhibitors and immunotherapy, preclinical research suggest that FGF/FGFR signaling is involved in regulating the tumor microenvironment (TME) including immune cells, vasculogenesis, and epithelial-mesenchymal transition (EMT). This raises the possibility that ICB in combination with FGFR-tyrosine kinase inhibitors (FGFR-TKIs) may be feasible for treatment option for patients with dysregulated FGF/FGFR signaling. Conclusion Here, we review the role of FGF/FGFR signaling in TME regulation and the potential mechanisms of FGFR-TKI in combination with ICB. In addition, we review clinical data surrounding ICB alone or in combination with FGFR-TKI for the treatment of FGFR-dysregulated tumors, highlighting that FGFR inhibitors may sensitize the response to ICB by impacting various stages of the “cancer-immune cycle”. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1186/s12943-023-01761-7 |
| DOI: |
10.1186/s12943-023-01761-7.pdf |
| DOI: |
10.1186/s12943-023-01761-7/fulltext.html |
| الإتاحة: |
https://doi.org/10.1186/s12943-023-01761-7Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.1DBEED57 |
| قاعدة البيانات: |
BASE |
