دورية أكاديمية
Screening of Chemical Dyes in Traditional Chinese Medicine by HPTLC-MS
| العنوان: | Screening of Chemical Dyes in Traditional Chinese Medicine by HPTLC-MS |
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| المؤلفون: | He, Fengyan, He, Yi, Zheng, Xiaowei, Wang, Ruizhong, Lu, Jing, Dai, Zhong, Ma, Shuangcheng |
| المصدر: | Journal of AOAC INTERNATIONAL ; volume 101, issue 3, page 686-694 ; ISSN 1060-3271 1944-7922 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Pharmacology, Agronomy and Crop Science, Environmental Chemistry, Food Science, Analytical Chemistry |
| الوصف: | It has been uncovered that chemical dyes are illegally used in traditional Chinese medicines to brighten color and cover up inferiority, which threaten the safety of patients. In the present study, an HPTLC-MS method was developed for the effective screening of 11 chemical dyes (Sudan I, II, III, and IV; 808 Scarlet; Sudan Red 7B; malachite green; Basic Orange 2; auramine; Orange II; and erythrosine) in traditional Chinese medicine (TCM) raw materials and Chinese patent medicines. Firstly, unwashed HPTLC plates were chosen by comparing the background signals of the TLC plates used directly and prewashed with analytical grade and HPLC grade solvents. Twice developments were conducted to isolate chemical dyes of different polarity. Possible adulterants were preliminarily identified by comparing Rf values and in situ UV-Vis spectra with those of the references. Further confirmation was conducted by tandem MS analysis via an elution head-based TLC-MS interface. Sudan I and IV, 808 Scarlet, and Orange II were successfully detected in eight batches of TCM. The proposed method could be applied as a reliable technology for the screening of chemical dyes in TCM. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.5740/jaoacint.17-0298 |
| الإتاحة: | https://doi.org/10.5740/jaoacint.17-0298Test http://academic.oup.com/jaoac/article-pdf/101/3/686/32427111/jaoac0686.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.1D990CE1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5740/jaoacint.17-0298 |
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