دورية أكاديمية
Dietary Factors and Endometrial Cancer Risk: A Mendelian Randomization Study
| العنوان: | Dietary Factors and Endometrial Cancer Risk: A Mendelian Randomization Study |
|---|---|
| المؤلفون: | Xuemin Wang, Dylan M. Glubb, Tracy A. O’Mara |
| المصدر: | Nutrients, Vol 15, Iss 3, p 603 (2023) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | endometrial cancer, micronutrients, vitamins, minerals, protein, carbohydrate, Nutrition. Foods and food supply, TX341-641 |
| الوصف: | Given the strong association between obesity and endometrial cancer risk, dietary factors may play an important role in the development of this cancer. However, observational studies of micro- and macronutrients and their role in endometrial cancer risk have been inconsistent. Clarifying these relationships are important to develop nutritional recommendations for cancer prevention. We performed two-sample Mendelian randomization (MR) to investigate the effects of circulating levels of 15 micronutrients (vitamin A (retinol), folate, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, β-carotene, calcium, copper, iron, magnesium, phosphorus, selenium, and zinc) as well as corrected relative macronutrient intake (protein, carbohydrate, sugar and fat) on risks of endometrial cancer and its subtypes (endometrioid and non-endometrioid histologies). Genetically predicted vitamin C levels were found to be strongly associated with endometrial cancer risk. There was some evidence that genetically predicted relative intake of macronutrients (carbohydrate, sugar and fat) affects endometrial cancer risk. No other significant association were observed. Conclusions: In summary, these findings suggest that vitamin C and macronutrients influence endometrial cancer risk but further investigation is required. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2072-6643 |
| العلاقة: | https://www.mdpi.com/2072-6643/15/3/603Test; https://doaj.org/toc/2072-6643Test; https://doaj.org/article/e4b37620c6874b1aa3df17cbe65a6226Test |
| DOI: | 10.3390/nu15030603 |
| الإتاحة: | https://doi.org/10.3390/nu15030603Test https://doaj.org/article/e4b37620c6874b1aa3df17cbe65a6226Test |
| رقم الانضمام: | edsbas.1D847DBC |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726643 |
|---|---|
| DOI: | 10.3390/nu15030603 |