دورية أكاديمية
Prognostic Clinical and Biologic Features for Overall Survival after Relapse in Childhood Medulloblastoma
| العنوان: | Prognostic Clinical and Biologic Features for Overall Survival after Relapse in Childhood Medulloblastoma |
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| المؤلفون: | Huybrechts, Sophie, Le Teuff, Gwénaël, Tauziède-Espariat, Arnault, Rossoni, Caroline, Chivet, Anaïs, Indersie, Émilie, Varlet, Pascale, Puget, Stéphanie, Abbas, Rachid, Ayrault, Olivier, Guerrini-Rousseau, Léa, Grill, Jacques, Valteau-Couanet, Dominique, Dufour, Christelle |
| المساهمون: | Centre Hospitalier de Luxembourg Luxembourg (CHL), Institut Gustave Roussy (IGR), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Biomarqueurs en imagerie : neuro développement et pathologies cérébrales (Ima-Brain Paris ), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), CHU Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biothérapies des maladies génétiques et cancers, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Signalisation, radiobiologie et cancer, Institut Curie Paris -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Prédicteurs moléculaires et nouvelles cibles en oncologie (PMNCO), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay |
| المصدر: | ISSN: 2072-6694. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2020 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | salvage radiotherapy, time to relapse, outcome after relapse, pediatric, molecular subgrouping, recurrent medulloblastoma, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology |
| الوصف: | International audience ; Despite progress in the biology and upfront treatment of childhood medulloblastoma, relapse is almost universally fatal. No standardized treatment has so far been established for these patients. By determining which characteristics are prognostic after relapse, treatment strategies may be optimized for each of these children. We demonstrated that molecular subgroup at diagnosis is a relevant prognostic factor of outcome after relapse. Moreover, we showed that time to relapse and the use of salvage radiotherapy at relapse might have a potential impact on post-relapse survival. Our data suggest that ongoing efforts toward a better understanding of the biology, timing and type of relapse would be important to understand the determinants of tumor behavior at relapse. This could help us address more specific questions on the best surveillance strategies after completion of the treatment and the introduction of risk-stratified second-line treatment strategies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03405534; https://hal.archives-ouvertes.fr/hal-03405534Test; https://hal.archives-ouvertes.fr/hal-03405534/documentTest; https://hal.archives-ouvertes.fr/hal-03405534/file/Huybrechts_Cancers_2021.pdfTest |
| DOI: | 10.3390/cancers13010053 |
| الإتاحة: | https://doi.org/10.3390/cancers13010053Test https://hal.archives-ouvertes.fr/hal-03405534Test https://hal.archives-ouvertes.fr/hal-03405534/documentTest https://hal.archives-ouvertes.fr/hal-03405534/file/Huybrechts_Cancers_2021.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.1D7A281F |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers13010053 |
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