دورية أكاديمية
Quantification of active pharmaceutical ingredients in commercially available poly pharmaceutical tablets by means of DSC
| العنوان: | Quantification of active pharmaceutical ingredients in commercially available poly pharmaceutical tablets by means of DSC |
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| المؤلفون: | Talik, Przemysław, Czerniecka, Ewa, Hubicka, Urszula, Krzek, Jan |
| سنة النشر: | 2017 |
| المجموعة: | Jagiellonian University Repository |
| مصطلحات موضوعية: | differential scanning calorimetry, DSC, paracetamol, ibuprofen |
| الوصف: | Differential scanning calorimetry is the first line technique indispensable for industrial quality controllaboratories and, next to many routine applications, could be used in quantitative assays. For this purpose, a relationship between the signal value of analyte (enthalpy change ΔH) and its concentration in the matrix isused. However, there are several limitations of its application, concerning solid state interactions between APIs, other APIs and/or coexisting excipients. With respect to their physical properties, it is known that amorphization state and/or permanent particle deformation can produce relatively large areas of interparticle contact and thus high particle-particle bonding forces. Finally, it may affect the DSC quantitative measurements. The problem was shown using commercially available, different poly component tablets containing ibuprofen in the presence of pseudoephedrine hydrochloride or paracetamol and coexisting excipients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0001-6837 2353-5288 |
| العلاقة: | Acta Poloniae Pharmaceutica. Drug Research, T. 74, nr 4, s. 1057-1062; https://ruj.uj.edu.pl/xmlui/handle/item/140961Test; http://ptfarm.pl/en/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/26980Test |
| الإتاحة: | https://ruj.uj.edu.pl/xmlui/handle/item/140961Test http://ptfarm.pl/en/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/26980Test |
| حقوق: | Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa ; http://creativecommons.org/licenses/by-nc/4.0/pl/legalcodeTest |
| رقم الانضمام: | edsbas.1CF4DF55 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00016837 23535288 |
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