دورية أكاديمية
Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma
| العنوان: | Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma |
|---|---|
| المؤلفون: | Sabina Sanegre, Núria Eritja, Carlos de Andrea, Juan Diaz-Martin, Ángel Diaz-Lagares, María Amalia Jácome, Carmen Salguero-Aranda, David García Ros, Ben Davidson, Rafel Lopez, Ignacio Melero, Samuel Navarro, Santiago Ramon y Cajal, Enrique de Alava, Xavier Matias-Guiu, Rosa Noguera |
| المصدر: | Frontiers in Cell and Developmental Biology, Vol 9 (2021) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | tumor-host interface, tumor microenvironment, extracellular matrix, reticular fibers, immune cells, gene expression, Biology (General), QH301-705.5 |
| الوصف: | The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. Herein we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression, and epigenetic profiles of classified aggressive primary uterine adenocarcinomas (24 patients) and leiomyosarcomas (11 patients). Sections of formalin-fixed samples before and after microdissection were scanned and studied. Reticular fiber architecture and immune cell infiltration were analyzed by automatized algorithms in colocalized regions of interest. Despite morphometric resemblance between reticular fibers and high presence of macrophages, we found some variance in other immune cell populations and distinctive gene expression and cell adhesion-related methylation signatures. Although no evident overall differences in immune response were detected at the gene expression and methylation level, impaired antimicrobial humoral response might be involved in uterine leiomyosarcoma spread. Similarities found at the invasive tumor front of uterine adenocarcinomas and leiomyosarcomas could facilitate the use of common biomarkers and therapies. Furthermore, molecular and architectural characterization of the invasive front of uterine malignancies may provide additional prognostic information beyond established prognostic factors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2296-634X |
| العلاقة: | https://www.frontiersin.org/articles/10.3389/fcell.2021.670185/fullTest; https://doaj.org/toc/2296-634XTest; https://doaj.org/article/743805c8e0f34b5ba6114838c5cfc6a8Test |
| DOI: | 10.3389/fcell.2021.670185 |
| الإتاحة: | https://doi.org/10.3389/fcell.2021.670185Test https://doaj.org/article/743805c8e0f34b5ba6114838c5cfc6a8Test |
| رقم الانضمام: | edsbas.1CB1FC8F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2296634X |
|---|---|
| DOI: | 10.3389/fcell.2021.670185 |