التفاصيل البيبلوغرافية
| العنوان: |
The use of core needle biopsy as first-line in diagnosis of thyroid nodules reduces false negative and inconclusive data reported by fine-needle aspiration |
| المؤلفون: |
Trimboli, Pierpaolo, Nasrollah, Naim, Guidobaldi, Leo, Taccogna, Silvia, Cicciarella Modica, Davide, Amendola, Stefano, Romanelli, Francesco, Lenzi, Andrea, Nigri, Giuseppe, Centanni, Marco, Giovanella, Luca, Valabrega, Stefano, Crescenzi, Anna |
| بيانات النشر: |
BioMed Central Ltd. |
| سنة النشر: |
2014 |
| المجموعة: |
BioMed Central |
| مصطلحات موضوعية: |
Thyroid cancer, Core needle biopsy (CNB), Ultrasonography, Fine-needle aspiration (FNA) |
| الوصف: |
Background The reported reliability of core needle biopsy (CNB) is high in assessing thyroid nodules after inconclusive fine-needle aspiration (FNA) attempts. However, first-line use of CNB for nodules considered at risk by ultrasonography (US) has yet to be studied. The aim of this study were: 1) to evaluate the potential merit of using CNB first-line instead of conventional FNA in thyroid nodules with suspicious ultrasonographic features; 2) to compare CNB and FNA as a first-line diagnostic procedure in thyroid lesions at higher risk of cancer. Methods Seventy-seven patients with a suspicious-appearing, recently discovered solid thyroid nodule were initially enrolled as study participants. No patients had undergone prior thyroid fine-needle aspiration/biopsy. Based on study design, all patients were proposed to undergo CNB as first-line diagnostic aspiration, while those patients refusing to do so underwent conventional FNA. Results Five patients refused the study, and a total of 31 and 41 thyroid nodules were subjected to CNB and FNA, respectively. At follow-up, the overall rate of malignancy was of 80% (CNB, 77%; FNA, 83%). However, the diagnostic accuracy of CNB (97%) was significantly ( P < 0.05) higher than that of FNA (78%). In one benign lesion, CNB was inconclusive. Four (12%) of the 34 cancers of the FNA group were not initially diagnosed because of false negative (N = 1), indeterminate (N = 2) or not adequate (N = 1) samples. Conclusions CNB can reduce the false negative and inconclusive results of conventional FNA and should be considered a first-line method in assessing solid thyroid nodules at high risk of malignancy. |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| العلاقة: |
http://www.wjso.com/content/12/1/61Test |
| الإتاحة: |
http://www.wjso.com/content/12/1/61Test |
| حقوق: |
Copyright 2014 Trimboli et al.; licensee BioMed Central Ltd. |
| رقم الانضمام: |
edsbas.1C508052 |
| قاعدة البيانات: |
BASE |
