دورية أكاديمية
Effect of t (11;14) Abnormality on Outcomes of Patients With Newly Diagnosed Multiple Myeloma in the Connect MM Registry
| العنوان: | Effect of t (11;14) Abnormality on Outcomes of Patients With Newly Diagnosed Multiple Myeloma in the Connect MM Registry |
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| المؤلفون: | Gasparetto, Cristina, Jagannath, Sundar, Rifkin, Robert M., Durie, Brian G. M., Narang, Mohit, Terebelo, Howard R., Toomey, Kathleen, Hardin, James W., Wagner, Lynne, Ailawadhi, Sikander, Omel, James L., Srinivasan, Shankar, Dhalla, Mazaher, Catamero, Donna, Kitali, Amani, Agarwal, Amit, Abonour, Rafat, Connect MM Registry Investigators |
| المساهمون: | Medicine, School of Medicine |
| المصدر: | Publisher |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
| مصطلحات موضوعية: | Community, Survival, Translocation, African American, Real-world |
| الوصف: | Background: The t (11;14) (q13;32) translocation [t (11;14)] is present in ∼20% of patients with newly diagnosed multiple myeloma (NDMM), but studies examining its prognostic ability have yielded divergent results, and data are lacking on outcomes from first-line therapy. Patients and methods: Data from the Connect MM Registry, a large US, multicenter, prospective observational cohort study of patients with NDMM were used to examine the effect of t (11;14) status on first-line therapy outcomes in the Overall population (n = 1574) and race groups (African American [AA] vs. non-African American [NAA]). Results: Baseline characteristics were generally similar between patients with (n = 378) and without (n = 1196) t (11;14). Prevalence of t (11;14) was similar by race (AA, 27%; NAA, 24%). In the overall population, regardless of first-line therapy, t (11;14) status did not affect progression-free survival (hazard ratio, 1.02; P = 0.7675) or overall survival (hazard ratio, 0.99; P = .9417). AA patients with t (11;14) had higher likelihood of death (Nominal Cox regression P = .0298) vs. patients without t (11;14). Conclusions: Acknowledging observational study and inferential limitations, this exploratory analysis of a predominantly community-based population suggests that t (11;14) is a neutral prognostic factor in the general MM population but may be a negative factor for overall survival in AA patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Clinical Lymphoma, Myeloma and Leukemia; Gasparetto C, Jagannath S, Rifkin RM, et al. Effect of t (11;14) Abnormality on Outcomes of Patients With Newly Diagnosed Multiple Myeloma in the Connect MM Registry. Clin Lymphoma Myeloma Leuk. 2022;22(3):149-157. doi:10.1016/j.clml.2021.08.007; https://hdl.handle.net/1805/40418Test |
| الإتاحة: | https://doi.org/10.1016/j.clml.2021.08.007Test https://hdl.handle.net/1805/40418Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.1B99E62C |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |