دورية أكاديمية
The role of cannabinoids in bone metabolism: A new perspective for bone disorders
| العنوان: | The role of cannabinoids in bone metabolism: A new perspective for bone disorders |
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| المؤلفون: | Saponaro F., Ferrisi R., Gado F., Polini B., Saba A., Manera C., Chiellini G. |
| المساهمون: | F. Saponaro, R. Ferrisi, F. Gado, B. Polini, A. Saba, C. Manera, G. Chiellini |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Bone cancer, Bone remodeling, Cannabinoid receptor type 2 (CB2R), Endocannabinoids system (ECS), Osteoporosi, Antineoplastic Agent, Bone Density Conservation Agent, Bone Neoplasm, Bone Resorption, Bone and Bone, Endocannabinoid, Gene Expression Regulation, Hematopoiesi, Human, Neoplasm Metastasi, Osteoblast, Osteoclast, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Receptors, Cannabinoid, Signal Transduction, Settore CHIM/08 - Chimica Farmaceutica |
| الوصف: | Novel interest has arisen in recent years regarding bone, which is a very complex and dynamic tissue deputed to several functions ranging from mechanical and protective support to hematopoiesis and calcium homeostasis maintenance. In order to address these tasks, a very refined, continuous remodeling process needs to occur involving the coordinated action of different types of bone cells: osteoblasts (OBs), which have the capacity to produce newly formed bone, and osteo-clasts (OCs), which can remove old bone. Bone remodeling is a highly regulated process that re-quires many hormones and messenger molecules, both at the systemic and the local level. The whole picture is still not fully understood, and the role of novel actors, such as the components of the endocannabinoids system (ECS), including endogenous cannabinoid ligands (ECs), cannabinoid receptors (CBRs), and the enzymes responsible for endogenous ligand synthesis and breakdown, is extremely intriguing. This article reviews the connection between the ECS and skeletal health, sup-porting the potential use of cannabinoid receptor ligands for the treatment of bone diseases associated with accelerated osteoclastic bone resorption, including osteoporosis and bone metastasis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34830256; info:eu-repo/semantics/altIdentifier/wos/WOS:000726851000001; volume:22; issue:22; firstpage:1; lastpage:22; numberofpages:22; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/2434/907533Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85118977590 |
| DOI: | 10.3390/ijms222212374 |
| الإتاحة: | https://doi.org/10.3390/ijms222212374Test http://hdl.handle.net/2434/907533Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1B850C9F |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms222212374 |
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