التفاصيل البيبلوغرافية
| العنوان: |
Interleukin‐28B (IL‐28B) single‐nucleotide polymorphisms and interferon plus ribavirin treatment outcome in Italian chronically HCV‐infected patients |
| المؤلفون: |
Riva, E., Scagnolari, C., Monteleone, K., Selvaggi, C., Picardi, A., Mazzarelli, C., Pizzigallo, E., Vincenzi, B., Carducci, A., Antonaci, S., Giannelli, G., Antonelli, G. |
| المصدر: |
Journal of Viral Hepatitis ; volume 19, issue 9, page 650-653 ; ISSN 1352-0504 1365-2893 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2012 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Summary. To determine the single or combined effect of both rs12979860 and rs8099917 SNPs on HCV treatment response, these variants were genotyped in samples from a cohort of 170 patients infected with different HCV genotypes (HCVGT). The favourable rs12979860 CC genotype was found only in patients with sustained or rapid virological responses (SVR/RVR) and at significantly high proportions in HCVGT1/4 SVR patients. A significant association was also found between the rs8099917 TT genotype and SVR in both HCVGT1/4 and HCVGT2/3 groups of patients. In contrast, we found that there was significantly more of the rs8099917 GG genotype in nonresponders (NR) than in SVR patients which suggests a good association of the minor homozygote GG with the lack of treatment response. The combination of rs12979860/rs8099917 CC/TT favourable genotypes was found only in SVR patients and matched the frequency observed for their rs12979860 CC genotypes alone. By contrast, the inverse unfavourable correlate rs12979860/rs8099917 TT/GG genotype was seen more in NR than in SVR patients as observed for the single GG genotype. This study confirms the impact of both rs12979860 and/or rs8099917 IL‐28B SNPs on treatment‐induced clearance of HCV‐RNA and demonstrates that the rs12979860 CC genotype is stronger than rs8099917 TT genotype in predicting a positive treatment response in HCVGT1/4 patients. The unfavourable rs8099917 GG genotype seems to be more important in predicting the failure of treatment response independently from HCV genotype. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/j.1365-2893.2012.01606.x |
| الإتاحة: |
https://doi.org/10.1111/j.1365-2893.2012.01606.xTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.1B7FD7A6 |
| قاعدة البيانات: |
BASE |
