دورية أكاديمية
Immunosuppressive regimen and interstitial fibrosis and tubules atrophy at 12 months postrenal transplant
| العنوان: | Immunosuppressive regimen and interstitial fibrosis and tubules atrophy at 12 months postrenal transplant |
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| المؤلفون: | Gelens, M.A., Steegh, F.M., van Hooff, J.P., van Suylen, R.J., Nieman, F.H.M., van Heurn, L.W.E., Peutz-Kootstra, C.J., Christiaans, M.H. |
| المصدر: | Gelens , M A , Steegh , F M , van Hooff , J P , van Suylen , R J , Nieman , F H M , van Heurn , L W E , Peutz-Kootstra , C J & Christiaans , M H 2012 , ' Immunosuppressive regimen and interstitial fibrosis and tubules atrophy at 12 months postrenal transplant ' , Clinical journal of the American Society of Nephrology , vol. 7 , no. 6 , pp. 1010-1017 . https://doi.org/10.2215/CJN.09030911Test |
| سنة النشر: | 2012 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | CHRONIC ALLOGRAFT NEPHROPATHY, RENAL-TRANSPLANTATION, HISTOLOGICAL ASSESSMENT, KIDNEY-TRANSPLANTATION, PROTOCOL BIOPSIES, GRAFT FUNCTION, CARDIAC DEATH, TACROLIMUS, RECIPIENTS, SIROLIMUS |
| الوصف: | BACKGROUND AND OBJECTIVES: Chronic renal transplant dysfunction is histopathologically characterized by interstitial fibrosis and tubular atrophy. This study investigated the relative contribution of baseline donor, recipient, and transplant characteristics to interstitial fibrosis and tubular atrophy score at month 12 after renal transplantation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This retrospective study includes all 109 consecutive recipients with adequate implantation and month 12 biopsies transplanted between April of 2003 and February of 2007. Immunosuppression regimen was tacrolimus and steroids (10 days) plus either sirolimus or mycophenolate mofetil. RESULTS: Average interstitial fibrosis and tubular atrophy score increased from 0.70 to 1.65 (P<0.001). In an adjusted multiple linear regression analysis, interstitial fibrosis and tubular atrophy score at month 12 was significantly related to donor type (donors after cardiac death versus living donor had interstitial fibrosis and tubular atrophy score+0.41, 95% confidence interval=0.05-0.76, P=0.02), baseline interstitial fibrosis and tubular atrophy, and immunosuppression regimen. Because of interaction between the latter two variables (P=0.002), results are given separately: recipients with a baseline interstitial fibrosis and tubular atrophy score of zero had a 0.60 higher score at month 12 (95% confidence interval=0.09-1.10, P=0.02) when mycophenolate mofetil-treated, whereas recipients with a baseline interstitial fibrosis and tubular atrophy score more than zero had a 0.38 higher score at month 12 (95% confidence interval=0.01-0.74, P=0.04) when sirolimus-treated. A higher score at month 12 correlated with a lower estimated GFR (rho=-0.45, P<0.001). CONCLUSIONS: These findings suggest that histologic assessment of a preimplantation biopsy may guide choice of immunosuppresion to maximize transplant survival and its interaction with type of immunosuppression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://cris.maastrichtuniversity.nl/en/publications/60deb833-da2d-4a33-8303-5a8961ceeab3Test |
| DOI: | 10.2215/CJN.09030911 |
| الإتاحة: | https://doi.org/10.2215/CJN.09030911Test https://cris.maastrichtuniversity.nl/en/publications/60deb833-da2d-4a33-8303-5a8961ceeab3Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1B7EDF5E |
| قاعدة البيانات: | BASE |
| DOI: | 10.2215/CJN.09030911 |
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