التفاصيل البيبلوغرافية
| العنوان: |
Cerebrospinal fluid production rate in various pathological conditions: a preliminary study |
| المؤلفون: |
Tariq, Kanza, Toma, Ahmed, Khawari, Sogha, Amarouche, Meriem, Elborady, Mohamed A., Thorne, Lewis, Watkins, Laurence |
| المصدر: |
Acta Neurochirurgica ; volume 165, issue 8, page 2309-2319 ; ISSN 0942-0940 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Neurology (clinical), Surgery |
| الوصف: |
Introduction The cerebrospinal fluid (CSF) production rate in humans is not clearly defined but is estimated to be 18–24 ml/h (Trevisi et al Croat Med J 55(4):377–387 (24); Casey and Vries Childs Nerv Syst 5(5):332–334 (8)). A frequent clinical observation is that patients often drain higher volumes of CSF than can be explained by the assumed ‘normal’ CSF production rate (PRcsf). In the National Hospital for Neurology and Neurosurgery PRcsf was recorded in a variety of common neurosurgical pathologies using LiquoGuard7, an automated peristaltic pump that accurately controls CSF drainage and maintains a pre-set CSF pressure. Methods A prospective observational study was performed from September 2021 onwards, on all patients in the National Hospital for Neurology and Neurosurgery who required CSF drainage as part of their ongoing treatment. The external drain was connected to a LiquoGuard7 pump (Möller Medical GmbH, Fulda, Germany), and the internal software of LiquoGuard7 was used to measure PRcsf. Statistical analysis used SPSS (version 25.0, IBM) by paired t test, comparing measured rates to hypothetical ‘normal’ CSF production rates calculated and published by Ekstedt (16–34ml/h) (Ekstedt J Neurol Neurosurg Psychiatry 41(4):345–353 (14)), assuming a similar distribution. Results PRcsf was calculated in 164 patients. Suspected normal pressure hydrocephalus ( n =41): PRcsf of 79ml/h±20SD ( p <0.0001). Post-surgical CSF leak ( n =26): PRcsf of 90ml/h±20SD ( p <0.0001). Subarachnoid haemorrhage ( n =34): PRcsf of 143ml/h±9SD ( p <0.0001). Intracerebral haemorrhage ( n =22): PRcsf of 137ml/h±20SD ( p <0.0001). Spinal lesions ( n =7): PRcsf of 130ml/h±20SD ( p <0.0032). Pituitary adenomas ( n =10): PRcsf of 29 ml/h±9SD ( p <0.049). Idiopathic intracranial hypertension ( n =15): PRcsf of 86ml/h±10SD ( p <0.0001). Decompensated long-standing overt ventriculomegaly ( n =4): PRcsf of 65ml/h±10SD ( p <0.0001). Cerebral infection ( n =5): PRcsf of 90ml/h±20SD ( p <0.0001). Conclusion ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1007/s00701-023-05650-2 |
| DOI: |
10.1007/s00701-023-05650-2.pdf |
| DOI: |
10.1007/s00701-023-05650-2/fulltext.html |
| الإتاحة: |
https://doi.org/10.1007/s00701-023-05650-2Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.1B6A2D52 |
| قاعدة البيانات: |
BASE |
