دورية أكاديمية
Dedicated 3D-T2-STIR-ZOOMit imaging improves demyelinating lesion detection in the anterior visual pathways of patients with multiple sclerosis
| العنوان: | Dedicated 3D-T2-STIR-ZOOMit imaging improves demyelinating lesion detection in the anterior visual pathways of patients with multiple sclerosis |
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| المؤلفون: | Pravata E., Roccatagliata L., Sormani M. P., Carmisciano L., Lienerth C., Sacco R., Kaelin-Lang A., Cianfoni A., Zecca C., Gobbi C. |
| المساهمون: | Pravata, E., Roccatagliata, L., Sormani, M. P., Carmisciano, L., Lienerth, C., Sacco, R., Kaelin-Lang, A., Cianfoni, A., Zecca, C., Gobbi, C. |
| بيانات النشر: | American Society of Neuroradiology |
| سنة النشر: | 2021 |
| المجموعة: | Università degli Studi di Genova: CINECA IRIS |
| مصطلحات موضوعية: | Adult, Female, Human, Magnetic Resonance Imaging, Male, Optic Neuriti, Reproducibility of Result, Visual Pathway, Multiple Sclerosis |
| الوصف: | Background and Purpose: Demyelinating lesions in the anterior visual pathways represent an underestimated marker of disease dissemination in patients with MS. We prospectively investigated whether a dedicated high-resolution MR imaging technique, the 3D-T2-STIR-ZOOMit, improves demyelinating lesion detection compared with the current clinical standard sequence, the 2DT2-STIR. Materials and Methods: 3T MR imaging of the anterior visual pathways (optic nerves, chiasm, and tracts) was performed using 3D-T2-STIR-ZOOMit and 2D-T2-STIR, in patients with MS and healthy controls. Two experienced neuroradiologists assessed, independently, demyelinating lesions using both sequences separately. 3D-T2-STIR-ZOOMit scan-rescan reproducibility was tested in 12 patients. The Cohen k was used for interrater agreement, and the intraclass correlation coefficient for reproducibility. Betweensequence detection differences and the effects of location and previous acute optic neuritis were assessed using a binomial mixed-effects model. Results: Forty-eight patients with MS with (n = 19) or without (n = 29) past optic neuritis and 19 healthy controls were evaluated. Readers' agreement was strong (3D-T2-STIR-ZOOMit: 0.85; 2D-T2-STIR: 0.90). The 3D-T2-STIR-ZOOMit scan-rescan intraclass correlation coefficient was 0.97 (95% CI, 0.96-0.98; P<.001), indicating excellent reproducibility. Overall, 3D-T2-STIR-ZOOMit detected more than twice the demyelinating lesions (n=89) than 2D-T2-STIR (n=43) (OR = 2.7; 95% CI, 1.7-4.1; P<.001). In the intracranial anterior visual pathway segments, 33 of the 36 demyelinating lesions (91.7%) detected by 3D-T2-STIR-ZOOMit were not disclosed by 2D-T2-STIR. 3D-T2-STIR-ZOOMit increased detection of demyelinating lesion probability by 1.8-fold in patients with past optic neuritis (OR = 1.8; 95% CI, 1.2-3.1; P=.01) and 5.9-fold in patients without past optic neuritis (OR = 5.9; 95% CI, 2.5-13.8; P<.001). No false-positive demyelinating lesions were detected in healthy controls. Conclusions: Dedicated ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33766824; info:eu-repo/semantics/altIdentifier/wos/WOS:000658573800013; volume:42; firstpage:1061; lastpage:1068; numberofpages:8; journal:AJNR, AMERICAN JOURNAL OF NEURORADIOLOGY; http://hdl.handle.net/11567/1068276Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85108339099 |
| DOI: | 10.3174/ajnr.A7082 |
| الإتاحة: | https://doi.org/10.3174/ajnr.A7082Test http://hdl.handle.net/11567/1068276Test |
| رقم الانضمام: | edsbas.1B3A4252 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3174/ajnr.A7082 |
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