دورية أكاديمية
Key factors associated with pulmonary sequelae in the follow-up of critically ill COVID-19 patients
| العنوان: | Key factors associated with pulmonary sequelae in the follow-up of critically ill COVID-19 patients |
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| المؤلفون: | Pérez García, Felipe, González, Jessica, Batlle Garcia, Jordi De, Benítez, Iván D., Torres, Gerard, Santisteve, Sally, Targa Dias Santos, Adriano, Gort Paniello, Clara, Moncusí Moix, Anna, Aguilà Balastegui, Maria, Seck, Fatty, Ceccato, Adrián, Ferrer Roca, Ricard, Motos, Anna, Riera del Brío, Jordi, Fernández, Laia, Menéndez, Rosario, Lorente, José Ángel, Peñuelas, Oscar, Garcia Gasulla, Dario, Peñasco Martín, Yhivian, Ricart Martí, Pilar, Abril Palomares, Elena, Aguilera, Luciano, Rodriguez, Alejandro, Boado Varela, Maria Victoria, Beteré Cubillo, Belén, Pozo Laderas, Juan Carlos, Solé Violan, Jordi, Salvador Adell, Inmaculada, Andrea Novo, Mariana, Barberán, José, Amaya Villar, Rosario, Garnacho Montero, José, Gómez, José M., Blandino Ortiz, Aaron, Tamayo Lomas, Luis, Úbeda, Alejandro, Catalán González, Mercedes, Sánchez Miralles, Angel, Martínez Varela, Ignacio, Jorge García, Ruth Noemí, Franco, Nieves, Gumucio Sanguino, Victor Daniel, Bustamante Munguira, Elena, Valdivia, Luis Jorge, Caballero, Jesús, Gallego, Elena, Rodríguez, Covadonga, Castellanos Ortega, Álvaro, Trenado, Josep, Marin Corral, Judith, Muñiz Albaiceta, Guillermo, De La Torre, María Del Carmen, Loza Vázquez, Ana, Vidal, Pablo, Añón Elizalde, José Manuel, Carbajales Pérez, Cristina, Sagredo, Victor, Carbonell Monleón, Cristina, Socias Crespí, Lorenzo, Barberà, Carme, Estella, Ángel, Diaz, Emili, Gonzalo Calvo, David de, Torres, Antoni, Barbé Illa, Ferran |
| المساهمون: | Universidad de Alcalá. Departamento de Biomedicina y Biotecnología. Unidad docente Microbiología y Parasitología |
| سنة النشر: | 2023 |
| المجموعة: | e_Buah - Biblioteca Digital de la Universidad de Alcalá |
| مصطلحات موضوعية: | COVID-19, CT abnormalities, ICU, Lung function, Sequelae, Medicina, Medicine |
| الوصف: | 11 p. ; Introduction: Critical COVID-19 survivors have a high risk of respiratory sequelae. Therefore, we aimed to identify key factors associated with altered lung function and CT scan abnormalities at a follow-up visit in a cohort of critical COVID-19 survivors. Methods: Multicenter ambispective observational study in 52 Spanish intensive care units. Up to 1327 PCR-con rmed critical COVID-19 patients had sociodemographic, anthropometric, comorbidity and lifestyle characteristics collected at hospital admission; clinical and biological parameters throughout hospital stay; and, lung function and CT scan at a follow-up visit. Results: The median [p25?p75] time from discharge to follow-up was 3.57 [2.77?4.92] months. Median age was 60 [53?67] years, 27.8% women. The mean (SD) percentage of predicted diffusing lung capacity for carbon monoxide (DLCO) at follow-up was 72.02 (18.33)% predicted, with 66% of patients having DLCO< 80% and 24% having DLCO< 60%. CT scan showed persistent pulmonary in ltrates, brotic lesions, and emphysema in 33%, 25% and 6% of patients, respectively. Key variables associated with DLCO< 60% were chronic lung disease (CLD) (OR: 1.86 (1.18?2.92)), duration of invasive mechanical ventilation (IMV) (OR: 1.56 (1.37?1.77)), age (OR [per-1-SD] (95%CI): 1.39 (1.18?1.63)), urea (OR: 1.16 (0.97?1.39)) and estimated glomerular ltration rate at ICU admission (OR: 0.88 (0.73?1.06)). Bacterial pneumonia (1.62 (1.11?2.35)) and duration of ventilation (NIMV (1.23 (1.06?1.42), IMV (1.21 (1.01?1.45)) and prone positioning (1.17 (0.98?1.39)) were associated with brotic lesions. Conclusion: Age and CLD, re ecting patients? baseline vulnerability, and markers of COVID-19 severity, such as duration of IMV and renal failure, were key factors associated with impaired DLCOand CT abnormalities. ; Instituto de Salud Carlos III ; Centro de Investigación Biomédica en Red ; Enfermedades Respiratorias ; Fundación Francisco Soria Melguizo ; FEDER |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0300-2896 |
| العلاقة: | info:eu-repo/grantAgreement/ISCIII//CIBERESUCICOVID/ES//; info:eu-repo/grantAgreement/ISCIII//COV20/00110/ES//; info:eu-repo/grantAgreement/ISCIII//CP19/00108/ES//; info:eu-repo/grantAgreement/ISCIII//CP20/00041/ES//; info:eu-repo/grantAgreement/ISCIII//CD21/00087/ES//; Archivos de Bronconeumologia, 2023, v. 59, n. 4, p. 205-215; http://hdl.handle.net/10017/60935Test; AR/0000047124; Archivos de Bronconeumologia; 59; 215; 205 |
| DOI: | 10.1016/j.arbres.2022.12.017 |
| الإتاحة: | https://doi.org/10.1016/j.arbres.2022.12.017Test http://hdl.handle.net/10017/60935Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1B34B659 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 03002896 |
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| DOI: | 10.1016/j.arbres.2022.12.017 |