دورية أكاديمية
Painless thyroiditis in a dupilumab-treated patient
| العنوان: | Painless thyroiditis in a dupilumab-treated patient |
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| المؤلفون: | Narantsatsral, Daramjav, Junko, Takagi, Hideyuki, Iwayama, Daisuke, Inukai, Hiroyuki, Takama, Yuka, Nomura, Syo, Hirase, Hiroyuki, Morita, Kazuo, Otake, Tetsuya, Ogawa, Akiyoshi, Takami |
| المصدر: | Endocrinology, Diabetes & Metabolism Case Reports ; volume 2020 ; ISSN 2052-0573 |
| بيانات النشر: | Bioscientifica |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Endocrinology, Diabetes and Metabolism, Internal Medicine |
| الوصف: | Summary Dupilumab an inhibitor of the interleukin (IL)-4R-alpha subunit is used for the treatment of allergic diseases. The patient was a 49-year-old man who received dupilumab for the treatment of severe atopic dermatitis. He presented hyperthyroidism with elevated thyroglobulin and anti-thyroid antibody negativity at 4 months after the initiation of therapy. On scintigraphy, the thyroid radioiodine uptake was low. Ultrasonography showed a diffuse hypoechoic area in the thyroid gland. A pathological study revealed lymphocytic infiltration. The administration of dupilumab was continued because of his atopic dermatitis that showed an excellent response. The patient`s hyperthyroidism changed to hypothyroidism 3 weeks later. Six months later his thyroid function normalized without any treatment. We herein describe the case of a patient with atopic dermatitis who developed painless thyroiditis under treatment with dupilumab. To the best of our knowledge, this is the first report of this event in the literature. Learning points: Dupilumab, a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, has been shown to be effective in the treatment atopic dermatitis and asthma with eosinophilia. Painless thyroiditis is characterized by transient hyperthyroidism and hypothyroidism and recovery without anti-thyroid treatment. This is the first report of painless thyroiditis as an adverse effect of dupilumab, although conjunctivitis and nasopharyngitis are the main adverse effects of dupilumab. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.1530/edm-20-0030 |
| الإتاحة: | https://doi.org/10.1530/edm-20-0030Test https://edm.bioscientifica.com/view/journals/edm/2020/1/EDM20-0030.xmlTest https://edm.bioscientifica.com/downloadpdf/journals/edm/2020/1/EDM20-0030.xmlTest |
| رقم الانضمام: | edsbas.1B15B6FD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1530/edm-20-0030 |
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