دورية أكاديمية
Mechanisms behind changes of neurodegeneration biomarkers in plasma induced by sleep deprivation
| العنوان: | Mechanisms behind changes of neurodegeneration biomarkers in plasma induced by sleep deprivation |
|---|---|
| المؤلفون: | Eide, Per Kristian, Lashkarivand, Aslan, Pripp, Are Hugo, Valnes, Lars Magnus, Hovd, Markus, Ringstad, Geir, Blennow, Kaj, Zetterberg, Henrik |
| المصدر: | Brain Communications , 5 (6) , Article fcad343. (2023) |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Acute sleep deprivation, brain metabolism, amyloid-β, molecular clearance, CSF-to-blood clearance |
| الوصف: | Acute sleep deprivation has been shown to affect cerebrospinal fluid and plasma concentrations of biomarkers associated with neurodegeneration, though the mechanistic underpinnings remain unknown. This study compared individuals who for one night were either subject to total sleep deprivation or free sleep, examining (1) plasma concentrations of neurodegeneration biomarkers the morning after sleep deprivation or free sleep, and (2) determining how overnight changes in biomarkers plasma concentrations correlate with indices of meningeal lymphatic and glymphatic clearance functions. Plasma concentrations of amyloid-β 40 and 42, phosphorylated tau peptide 181, glial fibrillary acid protein and neurofilament light were measured longitudinally in subjects who from Day 1 to Day 2 either underwent total sleep deprivation (n=7) or were allowed free sleep (n=21). The magnetic resonance imaging contrast agent gadobutrol was injected intrathecally, serving as a cerebrospinal fluid tracer. Population pharmacokinetic model parameters of gadobutrol cerebrospinal fluid-to-blood clearance were utilized as a proxy of meningeal lymphatic clearance capacity, and intrathecal contrast-enhanced magnetic resonance imaging as a proxy of glymphatic function. After one night of acute sleep deprivation, the plasma concentrations of amyloid-β 40 and 42 were reduced, but not the ratio, and concentrations of the other biomarkers were unchanged. The overnight change in amyloid-β 40 and 42 plasma concentrations in the sleep group correlated significantly with indices of meningeal lymphatic clearance capacity, while this was not seen for the other neurodegeneration biomarkers. However, overnight change in plasma concentrations of amyloid-β 40 and 42 did not correlate with the glymphatic marker. On the other hand, the overnight change in plasma concentration of phosphorylated tau peptide 181 correlated significantly with the marker of glymphatic function in the sleep-deprivation group, but not in the sleep group. The present data add to the ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10184479/1/fcad343.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10184479Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10184479/1/fcad343.pdfTest https://discovery.ucl.ac.uk/id/eprint/10184479Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.1B073E27 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |