التفاصيل البيبلوغرافية
| العنوان: |
An automatic entropy method to efficiently mask histology whole-slide images |
| المؤلفون: |
Song, Yipei, Cisternino, Francesco, Mekke, Joost M, de Borst, Gert J, de Kleijn, Dominique P V, Pasterkamp, Gerard, Vink, Aryan, Glastonbury, Craig A, van der Laan, Sander W, Miller, Clint L |
| المساهمون: |
Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Infection & Immunity, Centraal Diagnostisch Laboratorium, Pathologie Pathologen staf, CDL Onderzoek Pasterkamp |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Entropy, Histological Techniques, Humans, Image Processing, Computer-Assisted/methods, Machine Learning, Plaque, Atherosclerotic/diagnostic imaging, General, Journal Article |
| الوصف: |
Tissue segmentation of histology whole-slide images (WSI) remains a critical task in automated digital pathology workflows for both accurate disease diagnosis and deep phenotyping for research purposes. This is especially challenging when the tissue structure of biospecimens is relatively porous and heterogeneous, such as for atherosclerotic plaques. In this study, we developed a unique approach called 'EntropyMasker' based on image entropy to tackle the fore- and background segmentation (masking) task in histology WSI. We evaluated our method on 97 high-resolution WSI of human carotid atherosclerotic plaques in the Athero-Express Biobank Study, constituting hematoxylin and eosin and 8 other staining types. Using multiple benchmarking metrics, we compared our method with four widely used segmentation methods: Otsu's method, Adaptive mean, Adaptive Gaussian and slideMask and observed that our method had the highest sensitivity and Jaccard similarity index. We envision EntropyMasker to fill an important gap in WSI preprocessing, machine learning image analysis pipelines, and enable disease phenotyping beyond the field of atherosclerosis. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
2045-2322 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/448849Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/448849Test |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.1ADECE55 |
| قاعدة البيانات: |
BASE |
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