دورية أكاديمية
The impact of epigenetic mechanisms in migraine: Current knowledge and future directions
| العنوان: | The impact of epigenetic mechanisms in migraine: Current knowledge and future directions |
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| المؤلفون: | Gallardo López, Víctor J., vila-pueyo, marta, Pozo-Rosich, Patricia |
| المساهمون: | Institut Català de la Salut, Gallardo VJ, Vila-Pueyo M Grup de Recerca de Cefalea i Dolor Neurològic, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Pozo-Rosich P Grup de Recerca de Cefalea i Dolor Neurològic, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Unitat de Cefalees, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Migranya - Aspectes genètics, Expressió gènica, MicroARN, DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Headache Disorders::Headache Disorders, Primary::Migraine Disorders, Other subheadings::Other subheadings::Other subheadings::/genetics, CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs, PHENOMENA AND PROCESSES::Genetic Phenomena::Gene Expression Regulation::Epigenesis, Genetic, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos con cefaleas::cefaleas primarias::trastornos migrañosos, Otros calificadores::Otros calificadores::Otros calificadores::/genética, COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::elementos antisentido (genética)::ARN antiparalelo::microARN, FENÓMENOS Y PROCESOS::fenómenos genéticos::regulación de la expresión génica::epigénesis genética |
| الوصف: | DNA methylation; Biomarkers; Epigenetics ; Metilació de l'ADN; Biomarcadors; Epigenètica ; Metilación del ADN; Biomarcadores; Epigenética ; Background Epigenetic mechanisms, including DNA methylation, microRNAs and histone modifications, may modulate the genetic expression in migraine and its interaction with internal and external factors, such as lifestyle and environmental changes. Objective To summarize, contextualize and critically analyze the published literature on the current state of epigenetic mechanisms in migraine in a narrative review. Findings The studies published to date have used different approaches and methodologies to determine the role of epigenetic mechanisms in migraine. Epigenetic changes seem to be involved in migraine and are increasing our knowledge of the disease. Conclusions Changes in DNA methylation, microRNA expression and histone modifications could be utilized as biomarkers that would be highly valuable for patient stratification, molecular diagnosis, and precision medicine in migraine. ; The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: MV-P was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie IF grant agreement No. 101023175. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-00-931410-0 0-00-931410-5 |
| تدمد: | 1468-2982 |
| العلاقة: | Cephalalgia;43(2); https://doi.org/10.1177/03331024221145916Test; info:eu-repo/grantAgreement/EC/H2020/101023175; Gallardo VJ, Vila-Pueyo M, Pozo-Rosich P. The impact of epigenetic mechanisms in migraine: Current knowledge and future directions. Cephalalgia. 2023 Feb;43(2):1–12.; https://hdl.handle.net/11351/9904Test; 000931410500007 |
| DOI: | 10.1177/03331024221145916 |
| الإتاحة: | https://doi.org/10.1177/03331024221145916Test https://hdl.handle.net/11351/9904Test |
| حقوق: | Attribution-NonCommercial 4.0 International ; http://creativecommons.org/licenses/by-nc/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1AB80B70 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780009314100 0009314105 |
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| تدمد: | 14682982 |
| DOI: | 10.1177/03331024221145916 |