دورية أكاديمية
Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
| العنوان: | Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis |
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| المؤلفون: | Wu, X., Gardashova, G., Lan, L., Han, S., Zhong, C., Marquez, R.T., Wei, L., Wood, S., Roy, S., Gowthaman, R., Karanicolas, J., Gao, F.P., Dixon, D.A., Welch, D.R., Li, L., Ji, M., Aubé, J., Xu, L. |
| المصدر: | Communications Biology, 3(1) |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2020 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Antineoplastic Agents, Neoplasm Invasiveness, Animals, Breast Neoplasms, Tumor Burden, Mice, Nude, Cell Movement, Signal Transduction, ELAV-Like Protein 1, Inbred BALB C, Xenograft Model Antitumor Assays, Humans, Middle Aged, Cell Proliferation, Cell Line, Tumor, Forkhead Transcription Factors, Female, Lung Neoplasms |
| الوصف: | Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and elevated cytoplasmic HuR correlates with high-grade tumors and poor clinical outcome of breast cancer. HuR promotes tumorigenesis by regulating numerous proto-oncogenes, growth factors, and cytokines that support major tumor hallmarks including invasion and metastasis. Here, we report a HuR inhibitor KH-3, which potently suppresses breast cancer cell growth and invasion. Furthermore, KH-3 inhibits breast cancer experimental lung metastasis, improves mouse survival, and reduces orthotopic tumor growth. Mechanistically, we identify FOXQ1 as a direct target of HuR. KH-3 disrupts HuR–FOXQ1 mRNA interaction, leading to inhibition of breast cancer invasion. Our study suggests that inhibiting HuR is a promising therapeutic strategy for lethal metastatic breast cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/vypv-4b94Test; https://cdr.lib.unc.edu/downloads/kk91fw36t?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/kk91fw36tTest |
| DOI: | 10.17615/vypv-4b94 |
| الإتاحة: | https://doi.org/10.17615/vypv-4b94Test https://cdr.lib.unc.edu/downloads/kk91fw36t?file=thumbnailTest https://cdr.lib.unc.edu/downloads/kk91fw36tTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.1A932BD |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/vypv-4b94 |
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