دورية أكاديمية
Adjuvant-dependent impact of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus
| العنوان: | Adjuvant-dependent impact of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus |
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| المؤلفون: | Dillard, Jacob A., Taft-Benz, Sharon A., Knight, Audrey C., Anderson, Elizabeth J., Pressey, Katia D., Parotti, Breantié, Martinez, Sabian A., Diaz, Jennifer L., Sarkar, Sanjay, Madden, Emily A., De la Cruz, Gabriela, Adams, Lily E., Dinnon, Kenneth H., Leist, Sarah R., Martinez, David R., Schäfer, Alexandra, Powers, John M., Yount, Boyd L., Castillo, Izabella N., Morales, Noah L., Burdick, Jane, Evangelista, Mia Katrina D., Ralph, Lauren M., Pankow, Nicholas C., Linnertz, Colton L., Lakshmanane, Premkumar, Montgomery, Stephanie A., Ferris, Martin T., Baric, Ralph S., Baxter, Victoria K., Heise, Mark T. |
| المصدر: | Nature Communications, 15(1) |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2024 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Aluminum Hydroxide, Adjuvants, Immunologic, Female, COVID-19, SARS-CoV-2, COVID-19 Vaccines, Antibodies, Viral, Humans, Vaccine, Disease Models, Animal, Mice, Inbred BALB C, Animals, Vaccines, Inactivated, Severe acute respiratory syndrome-related coronavirus |
| الوصف: | Whole virus-based inactivated SARS-CoV-2 vaccines adjuvanted with aluminum hydroxide have been critical to the COVID-19 pandemic response. Although these vaccines are protective against homologous coronavirus infection, the emergence of novel variants and the presence of large zoonotic reservoirs harboring novel heterologous coronaviruses provide significant opportunities for vaccine breakthrough, which raises the risk of adverse outcomes like vaccine-associated enhanced respiratory disease. Here, we use a female mouse model of coronavirus disease to evaluate inactivated vaccine performance against either homologous challenge with SARS-CoV-2 or heterologous challenge with a bat-derived coronavirus that represents a potential emerging disease threat. We show that inactivated SARS-CoV-2 vaccines adjuvanted with aluminum hydroxide can cause enhanced respiratory disease during heterologous infection, while use of an alternative adjuvant does not drive disease and promotes heterologous viral clearance. In this work, we highlight the impact of adjuvant selection on inactivated vaccine safety and efficacy against heterologous coronavirus infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/c2sq-w405Test; https://cdr.lib.unc.edu/downloads/vh53x7148?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/vh53x7148Test |
| DOI: | 10.17615/c2sq-w405 |
| الإتاحة: | https://doi.org/10.17615/c2sq-w405Test https://cdr.lib.unc.edu/downloads/vh53x7148?file=thumbnailTest https://cdr.lib.unc.edu/downloads/vh53x7148Test |
| رقم الانضمام: | edsbas.1A69FCD0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/c2sq-w405 |
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