التفاصيل البيبلوغرافية
| العنوان: |
Nivolumab plus ipilimumab in metastatic melanoma: a critical appraisal focused on specific subpopulations |
| المؤلفون: |
Vázquez Montero, Lucía, Álamo de la Gala, María del Carmen, Cruz Merino, Luis de la |
| المساهمون: |
Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS151: Bioquímica médica. |
| بيانات النشر: |
Frontiers Media S.A. |
| سنة النشر: |
2024 |
| المجموعة: |
idUS - Deposito de Investigación Universidad de Sevilla |
| مصطلحات موضوعية: |
Nivolumab, Ipilimumab, Advanced melanoma, Safety, Efficacy |
| الوصف: |
The development of immune checkpoint inhibitors has revolutionized the landscape of treatment of advanced melanoma in recent years. Based on the efficacy results of the phase III CheckMate 067 trial, nivolumab in combination with ipilimumab is one of the first-line standard options for advanced melanoma along with pembrolizumab, nivolumab, and, recently, nivolumab plus relatlimab. Counterbalancing its efficacy, nivolumab plus ipilimumab is associated with severe immune-related toxicity. This article will review the efficacy and safety of the nivolumab plus ipilimumab combination in advanced melanoma across phase I, II, and III clinical trials that evaluated this approach. We also explore the benefit of the combination schedule across different subgroups of patients and possible predictive biomarkers for efficacy outcomes in order to elucidate which patients could be the best candidates for combination or single-agent therapy. Patients with BRAF-mutant tumours, asymptomatic brain metastases, or PD-L1- negative status appear to reach better survival outcomes with the combination relative to single-agent immunotherapy. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
Frontiers in Oncology, 13, 01-09.; https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1187840/fullTest; https://idus.us.es/handle//11441/155768Test |
| الإتاحة: |
https://idus.us.es/handle//11441/155768Test |
| حقوق: |
Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.19B3A31D |
| قاعدة البيانات: |
BASE |
