التفاصيل البيبلوغرافية
| العنوان: |
Sequential Cu(II)-Catalyzed Multicomponent C–N Coupling, Nucleophilic Addition, and Cyclization Cascade: A Diastereoselective Approach to Carboxamide-Embedded Hexahydrobenzofuran Core |
| المؤلفون: |
Anchal Saxena (14302339), Nayan Ghosh (1479316) |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, ii )- catalyzed, domino reactions serve, complex organic scaffolds, reaction proceeds via, assisted multicomponent reaction, ynamide intermediates, tethered cyclohexadienones, silica gel, powerful technique, one pot, nucleophilic addition, hydrative cyclization, excellent diastereoselectivity, diastereoselective approach, cyclization cascade |
| الوصف: |
Cascade or domino reactions serve as a powerful technique for the synthesis of complex organic scaffolds in one pot. Herein, a Cu(II)-catalyzed and silica gel-assisted multicomponent reaction (MCR) between bromoalkyne-tethered cyclohexadienones, amides, and water for the construction of hexahydrobenzofuran-3-carboxamide is developed. The reaction proceeds via a C–N coupling reaction followed by hydrative cyclization of ynamide intermediates. Notably, good to excellent diastereoselectivity is complementary of this reaction. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/Sequential_Cu_II_-Catalyzed_Multicomponent_C_N_Coupling_Nucleophilic_Addition_and_Cyclization_Cascade_A_Diastereoselective_Approach_to_Carboxamide-Embedded_Hexahydrobenzofuran_Core/21780928Test |
| DOI: |
10.1021/acs.joc.2c02320.s002 |
| الإتاحة: |
https://doi.org/10.1021/acs.joc.2c02320.s002Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.193A83F7 |
| قاعدة البيانات: |
BASE |
