دورية أكاديمية
Early effect markers and exposure determinants of metalworking fluids among metal industry workers: protocol for a field study
| العنوان: | Early effect markers and exposure determinants of metalworking fluids among metal industry workers: protocol for a field study |
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| المؤلفون: | Hopf, Nancy B., Bourgkard, Eve, Demange, Valerie, Hulo, Sebastien, Sauvain, Jean-Jacques, Levilly, Ronan, Jeandel, Fanny, Robert, Alain, Guichard, Yves, Pralong, Jacques Andre, Chérot-Kornobis, Nathalie, Edme, Jean-Louis, Wild, Pascal |
| المساهمون: | CHU Lille, Institut Pasteur de Lille, Université de Lille, IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483, IMPact de l’Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483 |
| سنة النشر: | 2024 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: | early effect biomarkers, oxidative stress, metalworking fluid, exposure biomarkers, occupational epidemiology, genotoxic effects |
| الوصف: | BACKGROUND: Exposure to aerosols from metalworking fluids (MWF) has previously been related to a series of adverse health outcomes (eg, cancer, respiratory diseases). Our present epidemiological study focuses on occupational exposures to MWF and a panel of exposure and effect biomarkers. We hypothesize that these health outcomes are caused by particle exposure that generates oxidative stress, leading to airway inflammation and ultimately to chronic respiratory diseases. We aimed to assess whether MWF exposure, in particular as characterized by its oxidative potential, is associated with biomarkers of oxidative stress and inflammation as well as genotoxic effects. OBJECTIVE: The ultimate goal is to develop exposure reduction strategies based on exposure determinants that best predict MWF-related health outcomes. The following relationships will be explored: (1) exposure determinants and measured exposure; (2) occupational exposure and preclinical and clinical effect markers; (3) exposure biomarkers and biomarkers of effect in both exhaled breath condensate and urine; and (4) biomarkers of effect, genotoxic effects and respiratory symptoms. METHODS: At least 90 workers from France and Switzerland (30 controls, 30 exposed to straight MWF and 30 to aqueous MWF) were followed over three consecutive days after a nonexposed period of at least two days. The exposure assessment is based on MWF, metal, aldehyde, and ultrafine particle number concentrations, as well as the intrinsic oxidative potential of aerosols. Furthermore, exposure biomarkers such as metals, metabolites of polycyclic aromatic hydrocarbons and nitrosamine are measured in exhaled breath condensate and urine. Oxidative stress biomarkers (malondialdehyde, 8-isoprostane, 8-hydroxy-2'-deoxyguanosine, nitrates, and nitrites) and exhaled nitric oxide, an airway inflammation marker, are repeatedly measured in exhaled breath condensate and urine. Genotoxic effects are assessed using the buccal micronucleus cytome assay. The statistical analyses will include ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/octet-stream; application/rdf+xml; charset=utf-8 |
| اللغة: | English |
| العلاقة: | JMIR research protocols; JMIR Res Protoc; http://hdl.handle.net/20.500.12210/59714Test |
| الإتاحة: | https://doi.org/20.500.12210/59714Test https://hdl.handle.net/20.500.12210/59714Test |
| حقوق: | Attribution 3.0 United States ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.193570E7 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |