دورية أكاديمية
In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts
| العنوان: | In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts |
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| المؤلفون: | Abellán, Alicia, Mensink Bout, Sara M., García Esteban, Raquel, Beneito, Andrea, Chatzi, Leda, Duarte Salles, Talita, Fernández Cabrera, Mariana F., García Aymerich, Judith, Granum, Berit, Iñiguez, Carmen, Jaddoe, Vincent W. V., Kannan, Kurunthachalam, Lertxundi Manterola, Aitana, López Espinosa, María José, Philippat, Claire, Sakhi, Amrit K., Santos, Susana, Siroux, Valérie, Sunyer, Jordi, Trasande, Leonardo, Vafeiadi, Marina, Vela Soria, Fernando, Yang, Tiffany C., Zabaleta Camino, Carlos, Vrijheid, Martine, Duijts, Liesbeth, Casas, Maribel |
| المساهمون: | European Commission |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | ADDI: Repositorio Institucional de la Universidad del País Vasco / Euskal Herriko Unibertsitatea (UPV/EHU - Basque Country University) |
| مصطلحات موضوعية: | bisphenol A, pregnancy, asthma, wheezing, lung function, mother-child cohort |
| الوصف: | [EN] BACKGROUND: In utero exposure to bisphenols, widely used in consumer products, may alter lung development and increase the risk of respiratory morbidity in the offspring. However, evidence is scarce and mostly focused on bisphenol A (BPA) only. OBJECTIVE: To examine the associations of in utero exposure to BPA, bisphenol F (BPF), and bisphenol S (BPS) with asthma, wheeze, and lung function in school-age children, and whether these associations differ by sex. METHODS: We included 3,007 mother-child pairs from eight European birth cohorts. Bisphenol concentrations were determined in maternal urine samples collected during pregnancy (1999-2010). Between 7 and 11years of age, current asthma and wheeze were assessed from questionnaires and lung function by spirometry. Wheezing patterns were constructed from questionnaires from early to mid-childhood. We performed adjusted random-effects meta-analysis on individual participant data. RESULTS: Exposure to BPA was prevalent with 90% of maternal samples containing concentrations above detection limits. BPF and BPS were found in 27% and 49% of samples. In utero exposure to BPA was associated with higher odds of current asthma (OR=1.13, 95% CI=1.01, 1.27) and wheeze (OR=1.14, 95% CI=1.01, 1.30) (p-interaction sex=0.01) among girls, but not with wheezing patterns nor lung function neither in overall nor among boys. We observed inconsistent associations of BPF and BPS with the respiratory outcomes assessed in overall and sex-stratified analyses. CONCLUSION: This study suggests that in utero BPA exposure may be associated with higher odds of asthma and wheeze among school-age girls. ; The research leading to these results has received funding from Instituto de Salud Carlos III and European Union’s FEDER funds (CP16/00128 – the ENDOLUNG project, and PI17/01194 – the INMA-Ado-Respi Project), the European Community’s Seventh Framework Programme (FP7/2007–206) under grant agreement no 308,333 - the HELIX project –, and from the EC’s Horizon 2020 research and innovation ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1873-6750 |
| العلاقة: | info:eu-repo/grantAgreement/EC/FP7/308333; info:eu-repo/grantAgreement/EC/H2020/874583; info:eu-repo/grantAgreement/EC/H2020/733206; info:eu-repo/grantAgreement/EC/H2020/824989; info:eu-repo/grantAgreement/EC/H2020/261357; info:eu-repo/grantAgreement/EC/H2020/603794; info:eu-repo/grantAgreement/EC/H2020/634453; https://www.sciencedirect.com/science/article/pii/S0160412022001040?via%3DihubTest; Environment International 162 : (2022) // Article ID 107178; http://hdl.handle.net/10810/56132Test |
| DOI: | 10.1016/j.envint.2022.107178 |
| الإتاحة: | https://doi.org/10.1016/j.envint.2022.107178Test http://hdl.handle.net/10810/56132Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/3.0/esTest/ ; © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0Test/) ; Atribución 3.0 España |
| رقم الانضمام: | edsbas.19206E32 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 18736750 |
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| DOI: | 10.1016/j.envint.2022.107178 |