دورية أكاديمية
Multimodal decoding of human liver regeneration.
| العنوان: | Multimodal decoding of human liver regeneration. |
|---|---|
| المؤلفون: | Matchett, KP, Wilson-Kanamori, JR, Portman, JR, Kapourani, CA, Fercoq, F, May, S, Zajdel, E, Beltran, M, Sutherland, EF, Mackey, JBG, Brice, M, Wilson, GC, Wallace, SJ, Kitto, L, Younger, NT, Dobie, R, Mole, DJ, Oniscu, GC, Wigmore, SJ, Ramachandran, P, Vallejos, CA, Carragher, NO, Saeidinejad, MM, Quaglia, A, Jalan, R, Simpson, KJ, Kendall, TJ, Rule, JA, Lee, WM, Hoare, M, Weston, CJ, Marioni, JC, Teichmann, SA, Bird, TG, Carlin, LM, Henderson, NC |
| بيانات النشر: | Springer Science and Business Media LLC //dx.doi.org/10.1038/s41586-024-07376-2 Nature |
| سنة النشر: | 2024 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Animals, Female, Humans, Male, Mice, Acetaminophen, Cell Lineage, Cell Movement, Cell Proliferation, Chemical and Drug Induced Liver Injury, Disease Models, Animal, Hepatocyte Growth Factor, Hepatocytes, Liver, Liver Failure, Acute, Liver Regeneration, Inbred C57BL, Necrosis, Regenerative Medicine, Single-Cell Gene Expression Analysis, Wound Healing |
| الوصف: | Acknowledgements: This work was supported by a Wellcome Trust Senior Research Fellowship in Clinical Science (ref. 219542/Z/19/Z) to N.C.H., a Chan Zuckerberg Initiative Seed Network Grant to N.C.H., and a Tenovus Scotland grant (E20-03) to K.P.M., S. J. Wallace and N.C.H. J.R.P. was supported by a Medical Research Council Precision Medicine PhD studentship. C.A.K. was a cross-disciplinary post-doctoral fellow (XDF) supported by funding from the University of Edinburgh and Medical Research Council (MC_UU_00009/2). T.G.B. was funded by the Wellcome Trust (ref. WT107492Z). S.M. was funded by Cancer Research UK core funding to the CRUK Beatson Institute (refs. A17196 and A31287). J.B.G.M. was supported by a CRUK programme grant (A23390). F.F., J.B.G.M. and L.M.C. were supported by CRUK core funding to the Beatson Institute (A31287) and CRUK core funding to L.M.C. (A23983; DRCRPG-Nov22/100007). D.J.M. was supported by a Medical Research Council Senior Clinical Fellowship (MR/P008887/1). P.R. was supported by a Medical Research Council Clinician Scientist Fellowship (MR/N008340/1) and Medical Research Council Senior Clinical Fellowship (MR/W015919/1). M.M.S. was supported by a Peter Samuel Fellowship. We thank the patients who donated liver tissue for this study; J. Davidson, J. Black, C. Ibbotson and A. Baird of the Scottish Liver Transplant Unit and the research nurses of the Wellcome Trust Clinical Research Facility for assistance with consenting patients for this study; the liver transplant coordinators and surgeons of the Scottish Liver Transplant Unit and the surgeons and staff of the Hepatobiliary Surgical Unit, Royal Infirmary of Edinburgh for assistance in procuring human liver samples; the US ALFSG network for assistance in procuring human liver samples; core facilities and services at the Beatson Institute, in particular the Biological Research Unit & the Beatson Advanced Imaging Resource (BAIR); G. Jacquemet for advice on Cellpose segmentation for IVM analysis; R. Insall and L. Machesky for helpful ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/zip; text/xml; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/369320Test |
| الإتاحة: | https://www.repository.cam.ac.uk/handle/1810/369320Test |
| رقم الانضمام: | edsbas.1901DF98 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |