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Choice and Outcomes of Rate Control versus Rhythm Control in Elderly Patients with Atrial Fibrillation: A Report from the REPOSI Study

التفاصيل البيبلوغرافية
العنوان: Choice and Outcomes of Rate Control versus Rhythm Control in Elderly Patients with Atrial Fibrillation: A Report from the REPOSI Study
المؤلفون: Francesco Paciullo, Marco Proietti, Vanessa Bianconi, Alessandro Nobili, Metteo Pirro, Pier Mannuccio Mannucci, Gregory HY Lip, Graziana Lupattelli, Mauro Tettamanti, Luca Pasina, Carlotta Franchi, Francesco Perticone, Francesco Salerno, Salvatore Corrao, Alessandra Marengoni, Giuseppe Licata, Francesco Violi, Gino Roberto Corazza, Maura Marcucci, Tarek Kamal Eldin, Maria Pia Donatella Di Blanca, Giovanna Lanzo, Sarah Astuto, Ilaria Ardoino, Laura Cortesi, Domenico Prisco, Elena Silvestri, Caterina Cenci, Giacomo Emmi, Gianni Biolo, Gianfranco Guarnieri, Michela Zanetti, Giovanni Fernandes, Massimiliano Chiuch, Massimo Vanoli, Giulia Grignani, Gianluca Casella, Edoardo Alessandro Pulixi, Mauro Bernardi, Silvia Li Bassi, Luca Santi, Giacomo Zaccherini, Elmo Mannarino, Ranuccio Nuti, Roberto Valenti, Martina Ruvio, Silvia Cappelli, Alberto Palazzuoli, Teresa Salvatore, Ferdinando Carlo Sasso, Domenico Girelli, Oliviero Olivieri, Thomas Matteazzi, Mario Barbagallo, Lidia Plances, Roberta Alcamo, Luigi Calvo, Maria Valenti, Marco Zoli, Raffaella Arnò, Franco Laghi Pasini, Pier Leopoldo Capecchi, Maurizio Bicchi, Giuseppe Palasciano, Maria Ester Modeo, Maria Peragine, Fabrizio Pappagallo, Stefania Pugliese, Carla Di Gennaro, Alfredo Postiglione, Maria Rosaria Barbella, Francesco De Stefano, Maria Domenica Cappellini, Giovanna Fabio, Sonia Seghezzi, Margherita Migone De Amicis, Marta Mancarella, Daniela Mari, Paolo Dionigi Rossi, Sarah Damanti, Barbara Brignolo Ottolini, Giulia Bonini, Emanuela Miceli, Marco Vincenzo Lenti, Donatella Padula, Giovanni Murialdo, Alessio Marra, Federico Cattaneo, Maria Beatrice Secchi, Davide Ghelfi, Luigi Anastasio, Lucia Sofia, Maria Carbone, Giovanni Davì, Maria Teresa Guagnano, Simona Sestili, Gerardo Mancuso, Daniela Calipari, Mosè Bartone, Maria Rachele Meroni, Paolo Cavallo Perin, Bartolomeo Lorenzati, Gabriella Gruden, Graziella Bruno, Cristina Amione, Paolo Fornengo, Rodolfo Tassara, Deborah Melis, Lara Rebella, Giuseppe Delitala, Vincenzo Pretti, Maristella Salvatora Masala, Chiara Pes, Luigi Bolondi, Leonardo Rasciti, Ilaria Serio, Filippo Rossi Fanelli, Antonio Amoroso, Alessio Molfino, Enrico Petrillo, Giuseppe Zuccalà, Francesco Franceschi, Guido De Marco, Cordischi Chiara, Sabbatini Marta, Gabriella D'Aurizio, Giuseppe Romanelli, Claudia Amolini, Deborah Chiesa, Antonio Picardi, Umberto Vespasiani Gentilucci, Paolo Gallo, Giorgio Annoni, Maurizio Corsi, Sara Zazzetta, Giuseppe Bellelli, Hajnalka Szabo, Franco Arturi, Elena Succurro, Mariangela Rubino, Giorgio Sesti, Paola Loria, Maria Angela Becchi, Gianfranco Martucci, Alessandra Fantuzzi, Mauro Maurantonio, Maria Grazia Serra, Maria Antonietta Bleve, Laura Gasbarrone, Maria Rosaria Sajeva, Antonio Brucato, Silvia Ghidoni, Paola Di Corato, Giancarlo Agnelli, Emanuela Marchesini, Fabrizio Fabris, Michela Carlon, Francesca Turatto, Aldo Baritusso, Annalisa Amabile, Elisabetta Omenetto, Paolo Scarinzi, Roberto Manfredini, Christian Molino, Marco Pala, Fabio Fabbian, Benedetta Boari, Alfredo De Giorgi, Giuseppe Paolisso, Maria Rosaria Rizzo, Maria Teresa Laieta, Giovanbattista Rini, Pasquale Mansueto, Ilenia Pepe, Claudio Borghi, Enrico Strocchi, Valeria De Sando, Ilaria Pareo, Carlo Sabbà, Francesco Saverio Vella, Patrizia Suppressa, Raffaella Valerio, Pasquale Agosti, Flavia Fontana, Francesca Loparco, Caterina Capobianco, Luigi Fenoglio, Christian Bracco, Alessia Valentina Giraudo, Elisa Testa, Cristina Serraino, Silvia Fargion, Paola Bonara, Giulia Periti, Marianna Porzio, Slivia Tiraboschi, Flora Peyvandi, Alberto Tedeschi, Raffaella Rossio, Barbara Ferrari, Valter Monzani, Valeria Savojardo, Christian Folli, Maria Magnini, Alessio Conca, Giulia Gobbo, Giada Pallini, Miriam Valenti, Carlo L Balduini, Giampiera Bertolino, Stella Provini, Federica Quaglia, Franco Dallegri, Luciano Ottonello, Luca Liberale, Wu Sheng Chin, Laura Carassale, Silvia Caporotundo, Giancarlo Traisci, Lucrezia De Feudis, Silvia Di Carlo, Nicola Lucio Liberato, Alberto Buratti, Tiziana Tognin, Giovanni Battista Bianchi, Sabrina Giaquinto, Francesco Purrello, Antonino Di Pino, Salvatore Piro, Renzo Rozzini, Lina Falanga, Elena Spazzini, Giuseppe Montrucchio, Elisabetta Greco, Pietro Tizzani, Paolo Petitti, Antonio Perciccante, Alessia Coralli, Raffaella Salmi, Piergiorgio Gaudenzi, Susanna Gamberini, Andrea Semplicini, Lucia Gottardo, Gianluigi Vendemiale, Gaetano Serviddio, Roberta Forlano, Cesare Masala, Antonio Mammarella, Valeria Raparelli, Stefania Basili, Ludovica Perri, Raffaele Landolfi, Massimo Montalto, Antonio Mirijello, Carla Vallone, Martino Bellusci, Donatella Setti, Filippo Pedrazzoli, Luigina Guasti, Luana Castiglioni, Andrea Maresca, Alessandro Squizzato, Marta Molaro, Marco Bertolotti, Chiara Mussi, Maria Vittoria Libbra, Andrea Miceli, Elisa Pellegrini, Lucia Carulli, Francesca Veltri, Angela Sciacqua, Michele Quero, Chiara Bagnato, Lidia Colangelo, Tania Falbo, Roberto De Giorgio, Mauro Serra, Valentina Grasso, Eugenio Ruggeri, Benzoni Ilaria, Andrea Salvi, Roberto Leonardi, Chiara Grassini, Ilenia Mascherona, Giorgio Minelli, Francesca Maltese, Giampaolo Damiani, William Capeci, Massimo Mattioli, Giuseppe Pio Martino, Lorenzo Biondi, Monica Ormas, Pietro Pettinari, Roberto Romiti, Silvia Messina, Federica Cavallaro, Riccardi Ghio, Serena Favorini, Anna Dal Col, Salvatore Minisola, Luciano Colangelo, Antonella Afeltra, Pamela Alemanno, Benedetta Marigliano, Maria Elena Pipita, Pietro Castellino, Julien Blanco, Luca Zanoli, Marco Cattaneo, Paola Fracasso, Maria Valentina Amoruso, Valter Saracco, Marisa Fogliati, Carlo Bussolino, Vittorio Durante, Giovanna Eusebi, Daniela Tirotta, Francesca Mete, Miriam Gino, Antonio Cittadini, Carlo Vigorito, Michele Arcopinto, Andrea Salzano, Emanuele Bobbio, Alberto Maria Marra, Domenico Sirico, Guido Moreo, Francesco Scopelliti, Francesca Gasparini, Melissa Cocca, Alberto Ballestrero, Fabio Ferrando, Sergio Berra, Simonetta Dassi, Maria Cristina Nava, Bruno Graziella, Stefano Baldassarre, Salvatore Fragapani, Giorgio Galanti, Gabriele Mascherini, Cristian Petri, Laura Stefani, Margherita Girino, Valeria Piccinelli, Francesco Nasso, Vincenza Gioffrè, Maria Pasquale, Giuseppe Scattolin, Sergio Martinelli, Mauro Turrin, Leonardo Sechi, Cristina Catena, Gianluca Colussi, Ramirez Duque Nieves, Muela Molinero Alberto, Abad Requejo Pedro, Lopez Pelaez Vanessa, Tamargo Lara, Corbella Viros Xavier, Formiga Francesc, Diez Manglano Jesus, Bejarano Tello Esperanza, Del Corral Behamonte Esther, Sevil Puras Maria, Manuel Romero, Pinilla Llorente Blanca, Lopez Gonzalez-Cobos Cristina, Villalba Garcia M Victoria, Lopez Saez, Juan Bosco, Sanz Baena Susana, Arroyo Gallego Marta, Gonzalez Becerra Concepcion, Fernandez Moyano Antonio, Mercedes Gomez Hernandez, Manuel Poyato Borrego, Pacheco Cuadros Raquel, Perez Rojas Florencia, Garcia Olid Beatriz, Carrascosa Garcia Sara, Gonzalez-Cruz Cervellera Alfonso, Peinado Martinez Marta, Sara Carrascosa Garcia, Ruiz Cantero Alberto, Albarracín Arraigosa Antonio, Godoy Guerrero Montserrat, Barón Ramos Miguel Ángel, Machin Jose Manuel, Novo Veleiro Ignacio, Alvela Suarez Lucía, Lopez Alfonso, Rubal Bran David, Iñiguez Vazquez Iria, Rios Prego Monica
المساهمون: Paciullo, Francesco, Proietti, Marco, Bianconi, Vanessa, Nobili, Alessandro, Pirro, Metteo, Mannuccio Mannucci, Pier, HY Lip, Gregory, Lupattelli, Graziana, Tettamanti, Mauro, Pasina, Luca, Franchi, Carlotta, Perticone, Francesco, Salerno, Francesco, Corrao, Salvatore, Marengoni, Alessandra, Licata, Giuseppe, Violi, Francesco, Roberto Corazza, Gino, Marcucci, Maura, Kamal Eldin, Tarek, Pia Donatella Di Blanca, Maria, Lanzo, Giovanna, Astuto, Sarah, Ardoino, Ilaria, Cortesi, Laura, Prisco, Domenico, Silvestri, Elena, Cenci, Caterina, Emmi, Giacomo, Biolo, Gianni, Guarnieri, Gianfranco, Zanetti, Michela, Fernandes, Giovanni, Chiuch, Massimiliano, Vanoli, Massimo, Grignani, Giulia, Casella, Gianluca, Alessandro Pulixi, Edoardo, Bernardi, Mauro, Li Bassi, Silvia, Santi, Luca, Zaccherini, Giacomo, Mannarino, Elmo, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Salvatore, Teresa, Carlo Sasso, Ferdinando, Girelli, Domenico, Olivieri, Oliviero, Matteazzi, Thoma, Barbagallo, Mario, Plances, Lidia, Alcamo, Roberta, Calvo, Luigi, Valenti, Maria, Zoli, Marco, Arnò, Raffaella, Laghi Pasini, Franco, Leopoldo Capecchi, Pier, Bicchi, Maurizio, Palasciano, Giuseppe, Ester Modeo, Maria, Peragine, Maria, Pappagallo, Fabrizio, Pugliese, Stefania, Di Gennaro, Carla, Postiglione, Alfredo, Rosaria Barbella, Maria, De Stefano, Francesco, Domenica Cappellini, Maria, Fabio, Giovanna, Seghezzi, Sonia, Migone De Amicis, Margherita, Mancarella, Marta, Mari, Daniela, Dionigi Rossi, Paolo, Damanti, Sarah, Brignolo Ottolini, Barbara, Bonini, Giulia, Miceli, Emanuela, Vincenzo Lenti, Marco, Padula, Donatella, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Beatrice Secchi, Maria, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Davì, Giovanni, Teresa Guagnano, Maria, Sestili, Simona, Mancuso, Gerardo
سنة النشر: 2018
المجموعة: Università degli Studi di Ferrara: CINECA IRIS
مصطلحات موضوعية: antiarrhythmic agent, anticoagulant agent, antithrombocytic agent, calcium channel blocking agent, digoxin
الوصف: Background: Among rate-control or rhythm-control strategies, there is conflicting evidence as to which is the best management approach for non-valvular atrial fibrillation (AF) in elderly patients. Design: We performed an ancillary analysis from the 'Registro Politerapie SIMI' study, enrolling elderly inpatients from internal medicine and geriatric wards. Methods: We considered patients enrolled from 2008 to 2014 with an AF diagnosis at admission, treated with a rate-control-only or rhythm-control-only strategy. Results: Among 1114 patients, 241 (21.6%) were managed with observation only and 122 (11%) were managed with both the rate- and rhythm-control approaches. Of the remaining 751 patients, 626 (83.4%) were managed with a rate-control-only strategy and 125 (16.6%) were managed with a rhythm-control-only strategy. Rate-control-managed patients were older (p = 0.002), had a higher Short Blessed Test (SBT; p = 0.022) and a lower Barthel Index (p = 0.047). Polypharmacy (p = 0.001), heart failure (p = 0.005) and diabetes (p = 0.016) were more prevalent among these patients. Median CHA2DS2-VASc score was higher among rate-control-managed patients (p = 0.001). SBT [odds ratio (OR) 0.97, 95% confidence interval (CI) 0.94-1.00, p = 0.037], diabetes (OR 0.48, 95% CI 0.26-0.87, p = 0.016) and polypharmacy (OR 0.58, 95% CI 0.34-0.99, p = 0.045) were negatively associated with a rhythm-control strategy. At follow-up, no difference was found between rate- and rhythm-control strategies for cardiovascular (CV) and all-cause deaths (6.1 vs. 5.6%, p = 0.89; and 15.9 vs. 14.1%, p = 0.70, respectively). Conclusion: A rate-control strategy is the most widely used among elderly AF patients with multiple comorbidities and polypharmacy. No differences were evident in CV death and all-cause death at follow-up.
نوع الوثيقة: article in journal/newspaper
وصف الملف: STAMPA
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29564755; info:eu-repo/semantics/altIdentifier/wos/WOS:000430197100008; volume:35; issue:4; firstpage:365; lastpage:373; numberofpages:9; journal:DRUGS & AGING; http://hdl.handle.net/11392/2425850Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85044181404; https://link.springer.com/article/10.1007/s40266-018-0532-8Test
DOI: 10.1007/s40266-018-0532-8
الإتاحة: https://doi.org/10.1007/s40266-018-0532-8Test
http://hdl.handle.net/11392/2425850Test
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.18E65196
قاعدة البيانات: BASE
الوصف
DOI:10.1007/s40266-018-0532-8