دورية أكاديمية
Expression of BMP-2 and TGF-β1 mRNA during healing of the rabbit mandible
| العنوان: | Expression of BMP-2 and TGF-β1 mRNA during healing of the rabbit mandible |
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| المؤلفون: | Tipoe, GL, Si, X, Jin, Y, Yang, L, White, FH |
| بيانات النشر: | //www.blackwellpublishing.com/journals/EOS Denmark |
| سنة النشر: | 1997 |
| المجموعة: | University of Hong Kong: HKU Scholars Hub |
| مصطلحات موضوعية: | In situ hybridization, Transforming growth factor-β1, Bone morphogenetic protein-2, Fracture healing, Cell Division - genetics, Mandibular Fractures - genetics - metabolism - pathology, RNA, Messenger - analysis - genetics, Transforming Growth Factor beta - analysis - genetics, Bone Morphogenetic Proteins - analysis - genetics |
| الوصف: | To identify the cell types which produce BMP and TGF-β during fracture healing and to elucidate the interactions between BMP and TGF-β in regulating cell proliferation and differentiation at various stages, an experimental model of fracture healing in the rabbit mandible was established and the expression of BMP-2 and TGF-β1 mRNA was studied at different healing stages by in situ hybridization. The results showed that undifferentiated mesenchymal cells, differentiating osteoblasts and chondroblasts, had higher levels of BMP-2 mRNA at the stage of intramembranous bone formation and early chondrogenesis, while the level of TGF-β1 mRNA was higher in chondrocytes and active differentiated osteoblasts during chondrogenesis and endochondral ossification, respectively. We conclude that BMP-2 expression was correlated with the differentiation of mesenchymal cells into osteoblasts and chondrocytes. TGF-β1 mRNA expression was closely associated with the active synthetic stage of osteoblasts and chondrocytes. These observations suggest that both BMP and TGF-β are involved in the regulation of fracture healing. BMP may play an important rôle in bone induction and early chondrogenesis, while TGF-β regulates the proliferation and active synthetic ability of chondrocytes and osteoblasts. © Munksgaard, 1997. ; link_to_subscribed_fulltext |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0909-8836 |
| العلاقة: | European Journal of Oral Sciences; http://www.scopus.com/mlt/select.url?eid=2-s2.0-0031202254&selection=ref&src=s&origin=recordpageTest; European Journal Of Oral Sciences, 1997, v. 105 n. 4, p. 325-330; 330; 28485; 9298364; eid_2-s2.0-0031202254; 325; http://hdl.handle.net/10722/67731Test; 105 |
| DOI: | 10.1111/j.1600-0722.1997.tb00248.x |
| الإتاحة: | https://doi.org/10.1111/j.1600-0722.1997.tb00248.xTest http://hdl.handle.net/10722/67731Test |
| حقوق: | The definitive version is available at onlinelibrary.wiley.com |
| رقم الانضمام: | edsbas.18BA5A42 |
| قاعدة البيانات: | BASE |
| تدمد: | 09098836 |
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| DOI: | 10.1111/j.1600-0722.1997.tb00248.x |