دورية أكاديمية
Inflammatory indexes as predictive factors for platinum sensitivity and as prognostic factors in recurrent epithelial ovarian cancer patients: a MITO24 retrospective study
| العنوان: | Inflammatory indexes as predictive factors for platinum sensitivity and as prognostic factors in recurrent epithelial ovarian cancer patients: a MITO24 retrospective study |
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| المؤلفون: | Farolfi A., Scarpi E., Greco F., Bergamini A., Longo L., Pignata S., Casanova C., Cormio G., Bologna A., Orditura M., Zavallone L., Attademo L., Galla V., Franzese E., Pigozzi E., Loizzi V., Giorda G., Giardina D., Cioffi R., De Giorgi U. |
| المساهمون: | Farolfi A., Scarpi E., Greco F., Bergamini A., Longo L., Pignata S., Casanova C., Cormio G., Bologna A., Orditura M., Zavallone L., Attademo L., Galla V., Franzese E., Pigozzi E., Loizzi V., Giorda G., Giardina D., Cioffi R., De Giorgi U. |
| سنة النشر: | 2020 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | ovarian cancer, platinum sensitivity, inflammatory indexes |
| الوصف: | Neutrophil-to-lymphocyte ratio (NLR) and systemic inflammatory index (SII) are prognostic factors in epithelial ovarian cancer (EOC). Their predictive value for platinum-sensitivity and their role in recurrent EOC are unknown. A total of 375 EOC patients were retrospectively analyzed. The correlation between baseline NLR and SII, and platinum-free interval (PFI) according to first line bevacizumab treatment were analyzed using logistic regression analyses adjusted for baseline patient characteristics. Subsequently NLR and SII calculated before second line treatment initiation were evaluated to identify a potential correlation with progression-free survival (PFS) and overall survival (OS) in platinum-sensitive and in platinum-resistant population. In multivariate analysis, NLR ≥ 3 is an independent predictive factor for PFI at 6months in the chemotherapy group (OR = 2.77, 95% CI 1.38–5.56, p = 0.004), not in bevacizumab treated patients. After having adjusted for ECOG performance status, histology, ascites, bevacizumab treatment at second line and BRCA status, NLR ≥ 3 and SII ≥ 730 are significantly associated with worse OS in platinum-sensitive (HR = 2.69, 95% CI 1.60–4.53, p = 0.002; HR = 2.11, 95% CI 1.29–3.43, p = 0.003, respectively), not in platinum-resistant EOC patients. Low NLR is an independentpredictive factorfor platinum-sensitivity in patients treated without bevacizumab. NLR and SII are prognostic factors in recurrent platinum-sensitive EOC patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33097745; info:eu-repo/semantics/altIdentifier/wos/WOS:000586493900005; volume:10; issue:1; firstpage:1; lastpage:8; numberofpages:8; journal:SCIENTIFIC REPORTS; https://hdl.handle.net/11585/966469Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85093980591; https://www.nature.com/articles/s41598-020-75316-xTest |
| DOI: | 10.1038/s41598-020-75316-x |
| الإتاحة: | https://doi.org/10.1038/s41598-020-75316-xTest https://hdl.handle.net/11585/966469Test https://www.nature.com/articles/s41598-020-75316-xTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.18ACE0E6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-020-75316-x |
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