دورية أكاديمية
Expression of CD52 in peripheral T-cell lymphoma.
| العنوان: | Expression of CD52 in peripheral T-cell lymphoma. |
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| المؤلفون: | PICCALUGA, PIER PAOLO, AGOSTINELLI, CLAUDIO, Righi S, ZINZANI, PIER LUIGI, Pileri S.A. |
| المساهمون: | Piccaluga PP, Agostinelli C, Righi S, Zinzani PL, Pileri SA. |
| سنة النشر: | 2007 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Lymphoma, T-Cell, Peripheral |
| الوصف: | Peripheral T-cell lymphoma unspecified (PTCL/U) is a rare tumor characterized by poor treatment response and a dismal prognosis. We studied CD52 expression in 97 PTCL/U cases by immunohistochemistry on tissue-microarrays. Furthermore, CD52 gene expression was studied in 28 cases for which RNA was available. We found that CD52 is expressed in approximately 40% of PTCLs/U at the same level as in normal T-lymphocytes. Although other factors may play a role in the in vivo response to alemtuzumab, an anti-CD52 monoclonal antibody, the estimation of CD52 expression may provide a rationale for the selection of patients with a higher probability of treatment response. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/17488672; info:eu-repo/semantics/altIdentifier/wos/WOS:000245411600023; volume:92; firstpage:566; lastpage:567; numberofpages:2; journal:HAEMATOLOGICA; http://hdl.handle.net/11585/51398Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-34547660727; http://www.haematologica.org/content/92/4/566Test |
| DOI: | 10.3324/haematol.10767 |
| الإتاحة: | https://doi.org/10.3324/haematol.10767Test http://hdl.handle.net/11585/51398Test http://www.haematologica.org/content/92/4/566Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1837A5D1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3324/haematol.10767 |
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