التفاصيل البيبلوغرافية
| العنوان: |
Table_1_Visual-spatial processing impairment in the occipital-frontal connectivity network at early stages of Alzheimer’s disease.docx |
| المؤلفون: |
Iván Plaza-Rosales, Enzo Brunetti, Rodrigo Montefusco-Siegmund, Samuel Madariaga, Rodrigo Hafelin, Daniela P. Ponce, María Isabel Behrens, Pedro E. Maldonado, Andrea Paula-Lima |
| سنة النشر: |
2023 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Neuroscience, Pathology, Health Care, Psychiatry (incl. Psychotherapy), Clinical Sciences not elsewhere classified, Central Nervous System, Aged Care Nursing, Aged Health Care, Protein Trafficking, mild cognitive impairment (MCI), spatial memory, virtual navigation, EEG, eye-tracking, Alzheimer’s disease |
| الوصف: |
Introduction Alzheimer’s disease (AD) is the leading cause of dementia worldwide, but its pathophysiological phenomena are not fully elucidated. Many neurophysiological markers have been suggested to identify early cognitive impairments of AD. However, the diagnosis of this disease remains a challenge for specialists. In the present cross-sectional study, our objective was to evaluate the manifestations and mechanisms underlying visual-spatial deficits at the early stages of AD. Methods We combined behavioral, electroencephalography (EEG), and eye movement recordings during the performance of a spatial navigation task (a virtual version of the Morris Water Maze adapted to humans). Participants (69–88 years old) with amnesic mild cognitive impairment–Clinical Dementia Rating scale (aMCI–CDR 0.5) were selected as probable early AD (eAD) by a neurologist specialized in dementia. All patients included in this study were evaluated at the CDR 0.5 stage but progressed to probable AD during clinical follow-up. An equal number of matching healthy controls (HCs) were evaluated while performing the navigation task. Data were collected at the Department of Neurology of the Clinical Hospital of the Universidad de Chile and the Department of Neuroscience of the Faculty of Universidad de Chile. Results Participants with aMCI preceding AD (eAD) showed impaired spatial learning and their visual exploration differed from the control group. eAD group did not clearly prefer regions of interest that could guide solving the task, while controls did. The eAD group showed decreased visual occipital evoked potentials associated with eye fixations, recorded at occipital electrodes. They also showed an alteration of the spatial spread of activity to parietal and frontal regions at the end of the task. The control group presented marked occipital activity in the beta band (15–20 Hz) at early visual processing time. The eAD group showed a reduction in beta band functional connectivity in the prefrontal cortices reflecting poor planning of ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/Table_1_Visual-spatial_processing_impairment_in_the_occipital-frontal_connectivity_network_at_early_stages_of_Alzheimer_s_disease_docx/22057676Test |
| DOI: |
10.3389/fnagi.2023.1097577.s005 |
| الإتاحة: |
https://doi.org/10.3389/fnagi.2023.1097577.s005Test
https://figshare.com/articles/dataset/Table_1_Visual-spatial_processing_impairment_in_the_occipital-frontal_connectivity_network_at_early_stages_of_Alzheimer_s_disease_docx/22057676Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.1832F3D7 |
| قاعدة البيانات: |
BASE |
