التفاصيل البيبلوغرافية
| العنوان: |
Viral kinetics in untreated versus treated acute HIV infection in prospective cohort studies in Thailand |
| المؤلفون: |
Ananworanich, Jintanat, Eller, Leigh Anne, Pinyakorn, Suteeraporn, Kroon, Eugene, Sriplenchan, Somchai, Fletcher, James LK, Suttichom, Duanghathai, Bryant, Christopher, Trichavaroj, Rapee, Dawson, Peter, Michael, Nelson, Phanuphak, Nittaya, Robb, Merlin L |
| المساهمون: |
University of Hawai'i |
| المصدر: |
Journal of the International AIDS Society ; volume 20, issue 1 ; ISSN 1758-2652 1758-2652 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2017 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Introduction : The extent of viral replication during acute HIV infection (AHI) influences HIV disease progression. However, information comparing viral load (VL) kinetics with and without antiretroviral therapy (ART) in AHI is limited. The knowledge gained could inform preventive strategies aimed at reducing VL during AHI and therapeutic strategies to alter the viral kinetics that may enhance the likelihood of achieving HIV remission. Methods : The analysis utilized VL data captured during the first year of HIV infection from two studies in Thailand: the RV217 study (untreated AHI, 30 participants and 412 visits) and the RV254 study (treated AHI, 235 participants and 2803 visits). Fiebig stages were I/II (HIV RNA+, HIV IgM−) and Fiebig III/IV (HIV IgM+, Western blot‐/indeterminate). Data were modelled utilizing spline effects within a linear mixed model, with a random intercept and slope to allow for between‐subject variability and adjustment for the differences in variability between studies. The number of knots in the quadratic spline basis functions was determined by comparing models with differing numbers of knots via the Akaike Information Criterion. Models were fit using PROC GLIMMIX in SAS v9.3. Results : At enrolment, there were 24 Fiebig I/II and 6 Fiebig III/IV individuals in the untreated group and 137 Fiebig I/II and 98 Fiebig III/IV individuals in the treated group. Overall, the median age was 27.5 years old, most were male (89%), and CRF01_AE was the most common HIV clade (76%). By day 12 (4 days after ART in RV254), the untreated group had a 2.7‐fold higher predicted mean VL level compared to those treated (predicted log VL 6.19 for RV217 and 5.76 for RV254, p = 0.05). These differences increased to 135‐fold by day 30 (predicted log VL 4.89 for RV217 and 2.76 for RV254) and 1148‐fold by day 120 (predicted log VL 4.68 for RV217 and 1.63 for RV254) ( p < 0.0001 for both) until both curves were similarly flat at about day 150 ( p = 0.17 between days 150 and 160). The VL trajectories were ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.7448/ias.20.1.21652 |
| DOI: |
10.7448/IAS.20.1.21652 |
| الإتاحة: |
https://doi.org/10.7448/ias.20.1.21652Test |
| حقوق: |
http://creativecommons.org/licenses/by/3.0Test/ |
| رقم الانضمام: |
edsbas.183039B2 |
| قاعدة البيانات: |
BASE |
