BLOOD PRESSURE VARIABILITY INCREASES THE RISK OF DIFFUSION-WEIGHTED IMAGING LESIONS IN INDIVIDUALS WITH SMALL VESSEL DISEASE
| العنوان: | BLOOD PRESSURE VARIABILITY INCREASES THE RISK OF DIFFUSION-WEIGHTED IMAGING LESIONS IN INDIVIDUALS WITH SMALL VESSEL DISEASE |
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| المؤلفون: | Wiegertjes, Kim |
| المصدر: | MODID-759a0011d80:Morressier |
| بيانات النشر: | Morressier |
| سنة النشر: | 2017 |
| الوصف: | Background: Recent studies have identified a role for diffusion-weighted imaging positive (DWI+) lesions in the origin of small vessel disease (SVD), however their etiology remains largely unknown. As hypertension and blood pressure (BP) variability are known risk factors for SVD, we investigated their role in DWI+ lesion occurrence in individuals with SVD. Methods: 54 individuals with SVD (mean age 70.2 years [SD 6.5], 63% male) underwent 10 monthly 3T MRI scans and parallel BP measurements. DWI+ lesions were visually identified on DWI scans as hyperintense lesions. Variability in BP was defined using the coefficient of variation (CV; SD/mean x 100%). We used Cox proportional hazard regression analysis to investigate the association between BP (mean, variability) and DWI+ lesions. Results: During a median follow-up of 39.5 weeks (interquartile range [IQR] 37.8-40.3), 9 participants (16.7%) had a DWI+ lesion. Individuals with DWI+ lesions had a higher systolic BP (SBP) (157 mmHg [IQR 140-177]) at baseline than individuals without DWI+ lesions (139 mmHg [IQR 128-150], p=0.042). However, in Cox regression, baseline SBP was not associated with DWI+ lesion occurrence, whereas high variability in SBP during the study period significantly increased the risk of developing a DWI+ lesion even after adjustment for baseline age (aHR 1.30 per one point increase in CV of SBP, 95% confidence interval [CI] 1.04 -1.64, p=0.02).Conclusions: Variability in SBP is associated with the risk of developing DWI+ lesions. Increased SBP variability is a potentially modifiable mechanism for DWI+ lesion occurrence in individuals with SVD. |
| نوع الوثيقة: | other/unknown material |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://openresearchlibrary.org/viewer/ceaa219c-5a7a-4270-8636-10f7aaa886b3Test; https://openresearchlibrary.org/ext/api/media/ceaa219c-5a7a-4270-8636-10f7aaa886b3/assets/external_content.pdfTest |
| DOI: | 10.26226/morressier.5cb58cfec668520010b56e46 |
| الإتاحة: | https://doi.org/10.26226/morressier.5cb58cfec668520010b56e46Test https://openresearchlibrary.org/viewer/ceaa219c-5a7a-4270-8636-10f7aaa886b3Test https://openresearchlibrary.org/ext/api/media/ceaa219c-5a7a-4270-8636-10f7aaa886b3/assets/external_content.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by-nc-nd/4.0/legalcodeTest |
| رقم الانضمام: | edsbas.18119D23 |
| قاعدة البيانات: | BASE |
| DOI: | 10.26226/morressier.5cb58cfec668520010b56e46 |
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