دورية أكاديمية
An Isothiazolanthrone-Based Self-Assembling Anticancer Color-Changing Dye for Concurrent Imaging and Monitoring of Cell Viability
| العنوان: | An Isothiazolanthrone-Based Self-Assembling Anticancer Color-Changing Dye for Concurrent Imaging and Monitoring of Cell Viability |
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| المؤلفون: | Gour, N., Kshtriya, V., Khatun, S., Bandyopadhyay, S., Ghosh, R., Koshti, B., Singh, R., Haque, A., Bhatia, D., Joshi, K. B., Boukhvalov, D. W., Nath, S., Rengan, A. K. |
| المصدر: | Chemistry – An Asian Journal ; Chemistry - An Asian Journal |
| بيانات النشر: | John Wiley and Sons Ltd |
| سنة النشر: | 2023 |
| المجموعة: | Ural Federal University (URFU): ELAR / Уральский федеральный университет: электронный архив УрФУ |
| مصطلحات موضوعية: | ANTICANCER PROPERTIES, CELL IMAGING, CHARGE TRANSFER, COMPUTATIONAL MODELING, FLUORESCENT DYE, SELF-ASSEMBLY, CELL CULTURE, CELLS, COMPUTATION THEORY, COMPUTERIZED TOMOGRAPHY, FLUORESCENCE, SELF ASSEMBLY, BIOLOGICAL EVALUATION, CELL VIABILITY, COLOR CHANGING, COMPUTATIONAL MODELLING, FLUORESCENT DYES, PHOTOPHYSICAL PROPERTIES, PHOTOPHYSICAL STUDIES, SELF-ASSEMBLING, SOLVENT, ANIMAL, CELL LINE, CELL SURVIVAL, MOUSE, PROCEDURES, SPECTROFLUOROMETRY, ANIMALS, MICE, SOLVENTS |
| الوصف: | We report the photophysical properties, self-assembly and biological evaluation of an isothiazolanthrone-based dye, 7-amino-6H-anthra[9,1-cd]isothiazol-6-one (AAT), which reveals anticancer properties and can be potentially used as dye for monitoring cell viability. The solvent-dependent photophysical studies suggest that the emission of AAT is sensitive to environment polarity due to which interesting changes in the colored emission may be observed owing to the charge transfer (CT) processes. AAT also self-assembles to tree-like branched morphologies and produce, a greenish emission inside the cells when imaged after short interval (15 mins) of incubation while a red fluorescence could be noted after 24 h. Interestingly, AAT also produce differential emission inside mouse normal cells as compared to its cancer cell lines since it possess anticancer activity. The experimental observations were also validated theoretically via computational modeling. © 2023 Wiley-VCH GmbH. ; Indian Council of Medical Research, ICMR: 45/13/2020‐/BIO/BMS; Science and Engineering Research Board, SERB: EMR/2016/003186, SPG/2021/000521; Ministry of Education and Science of the Russian Federation, Minobrnauka: FEUZ‐2023‐0013 ; NG, greatly acknowledge support from the SERB research grants (EMR/2016/003186; SPG/2021/000521) for funding. VK is grateful to ICMR, India for providing financial support under the Senior Research Fellowship No. 45/13/2020‐/BIO/BMS. BK thanks SHODH fellowship for funding and Indrashil University for infrastructure support. RS thanks CSIR‐UGC for the pre‐doctoral senior research fellowship. KBJ acknowledges Sophisticated Instrument Centre (SIC)‐Dr. Harisingh Gour Central University Sagar, India for AFM facility. DWB acknowledged support Ministry of Science and Higher Education of the Russian Federation (through the basic part of the government mandate, Project No. FEUZ‐2023‐0013) and Jiangsu Innovative and Entrepreneurial Talents Project. NG thanks Dr. Abhijit Patra, Mr. Subhadeep Das and Mr. Subhankar Kundu, ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1861-4728 |
| العلاقة: | Gour, N, Kshtriya, V, Khatun, S, Bandyopadhyay, S, Ghosh, R, Koshti, B, Singh, R, Haque, A, Bhatia, D, Joshi, KB, Boukhvalov, DW, Nath, S & Rengan, AK 2023, 'An Isothiazolanthrone‐Based Self‐Assembling Anticancer Color‐Changing Dye for Concurrent Imaging and Monitoring of Cell Viability', Chemistry - An Asian Journal, Том. 18, № 9, e202300044. https://doi.org/10.1002/asia.202300044Test; Gour, N., Kshtriya, V., Khatun, S., Bandyopadhyay, S., Ghosh, R., Koshti, B., Singh, R., Haque, A., Bhatia, D., Joshi, K. B., Boukhvalov, D. W., Nath, S., & Rengan, A. K. (2023). An Isothiazolanthrone‐Based Self‐Assembling Anticancer Color‐Changing Dye for Concurrent Imaging and Monitoring of Cell Viability. Chemistry - An Asian Journal, 18(9), [e202300044]. https://doi.org/10.1002/asia.202300044Test; Final; All Open Access, Green; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151455872&doi=10.1002%2fasia.202300044&partnerID=40&md5=d82c9296a0a8534ce2c01e42b6b155aaTest; https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c755ad567dfe0f83ec6324/original/self-assembly-and-photophysical-studies-of-an-unusual-red-colored-dye-which-show-green-fluorescence-in-cell-imaging.pdfTest; http://elar.urfu.ru/handle/10995/130362Test; 85151455872 |
| DOI: | 10.1002/asia.202300044 |
| الإتاحة: | https://doi.org/10.1002/asia.202300044Test http://elar.urfu.ru/handle/10995/130362Test https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c755ad567dfe0f83ec6324/original/self-assembly-and-photophysical-studies-of-an-unusual-red-colored-dye-which-show-green-fluorescence-in-cell-imaging.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess ; cc-by-nc-nd ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.17D400D5 |
| قاعدة البيانات: | BASE |
| تدمد: | 18614728 |
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| DOI: | 10.1002/asia.202300044 |