دورية أكاديمية
The ERK5 signal pathway and hepatic stellate cells activation proliferation ; ERK5信号通路与肝星状细胞的活化、增殖
| العنوان: | The ERK5 signal pathway and hepatic stellate cells activation proliferation ; ERK5信号通路与肝星状细胞的活化、增殖 |
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| المؤلفون: | Tang, Cheng-fang, Wang, Ying-hang |
| المصدر: | Global Journal of Integrated Chinese Medicine and Western Medicine; Vol 3, No 2 (2015); 20 ; 国际中西医结合杂志; Vol 3, No 2 (2015); 20 ; 國際中西醫結合雜誌; Vol 3, No 2 (2015); 20 ; 2375-4710 ; 2308-6025 ; 10.14725/gjicmwm.v3n2 |
| بيانات النشر: | New Century Science Press |
| سنة النشر: | 2015 |
| المجموعة: | New Century Science Press (NCSP) / 新世纪科学出版社 |
| مصطلحات موضوعية: | Extracellular signal-regulated kinase 5, Cell activation, Hepatic stellate cells, Liver fibrosis, 细胞外信号调节激酶5；细胞活化；肝星状细胞；肝纤维化 |
| الوصف: | Mitogen-activated protein kinase (MAPK) signaling pathway in vivo as one important signal transduction system, which includes the sub-family of extracellular signal-regulated kinase 1/2 (ERK1 / 2), p38 mitogen-activated protein kinase (p38MAPK), c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase 5 (ERK5). It has been reported, in the formation of liver fibrosis, hepatic stellate cells are the major effector cells. Hepatic stellate cell activation, proliferation, secretion of extracellular matrix, extracellular matrix deposition excessive liver fibrosis is the central link. This review will show briefly activating hepatic stellate cells association with liver fibrosis in ERK5 signaling pathway.It may provide a reliable theoretical basis for clinical, which propose new ideas and methods in clinical practice. ; 丝裂原活化蛋白激酶（MAPK）信号通路，作为生物体内重要的信号转导系统之一，其亚族主要包括了细胞外信号调节激酶1/2（ERK1/2）、p38丝裂原活化蛋白激酶（p38MAPK）、c-Jun氨基末端激酶（JNK）和细胞外信号调节激酶 5（ERK5）。已有文献报道，在肝纤维化的形成过程中，肝星状细胞为主要效应细胞，肝星状细胞的活化、增殖、分泌细胞外基质，过度的细胞外基质的沉积是形成肝纤维化的中心环节。ERK5信号通路与肝星状细胞的活化、增殖，肝纤维化存在着一定的关系。本综述通过简述ERK5信号通路与肝星状细胞的激活、肝纤维化形成之间的关联，阐明ERK5通路的作用机制，以期为肝纤维化的诊治提出新的思路和方法。 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | http://journal.newcenturyscience.com/index.php/gjicmwm/article/view/1297Test |
| DOI: | 10.14725/gjicmwm.v3n2a1297 |
| الإتاحة: | https://doi.org/10.14725/gjicmwm.v3n2a1297Test https://doi.org/10.14725/gjicmwm.v3n2Test http://journal.newcenturyscience.com/index.php/gjicmwm/article/view/1297Test |
| حقوق: | Authors of published by NCSP retain the copyright of their article, which is freely distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0), permitting the unrestricted use, distribution, and reproduction of the article in any medium, provided the original work is properly cited.The author is asked to grant New Century Science Press the first right to publish her or his article as the final, definitive, and citable Version of Scholarly Record. In turn, New Century Science Press will make the article in its entirety freely available on NCSP’s online platform, NCSP Online, with no subscription fee or article pay-to-view fee or any other form of access fee or any publication embargo being applied. ; 作者同意New Century Science Press以开放存取的出版方式出版其作品，并遵循由Creative Commons Attribution 4.0 International (CC BY 4.0)倡导的开放存取原则。New Century Science Press 获得作者作品的首次出版权。NCSP将为作者作品提供基于互联网的开放存取平台，面向全球用户提供免费浏览和全文下载。 |
| رقم الانضمام: | edsbas.17D12D23 |
| قاعدة البيانات: | BASE |
| DOI: | 10.14725/gjicmwm.v3n2a1297 |
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