دورية أكاديمية
Immunohistochemistry-based taxonomical classification of Bladder cancer predicts response to neoadjuvant chemotherapy
| العنوان: | Immunohistochemistry-based taxonomical classification of Bladder cancer predicts response to neoadjuvant chemotherapy |
|---|---|
| المؤلفون: | Font, Albert, Domènech, Montserrat, Raquel Benítez, Raquel, Rava, Marta, Marqués, Miriam, José L Ramírez, Pineda Sanjuan, Silvia, Domínguez-Rodríguez, Sara, Gago, José L., Badal, Josep, Carrato, Cristina, López, Héctor, Quer, Ariadna, Castellano, Daniel, Malats, Núria, Real, Francisco X. |
| المساهمون: | Mok, Samuel C. |
| بيانات النشر: | MDPI |
| سنة النشر: | 2020 |
| المجموعة: | Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| مصطلحات موضوعية: | 616-006.04, 612.017, 519.237, Basal/squamous-like tumors, Bladder cancer, Immunohistochemistry, Molecular taxonomy, Neoadjuvant chemotherapy, Oncología, Inmunología, Análisis Multivariante, 3207.13 Oncología, 2412 Inmunología, 1209.09 Análisis Multivariante |
| الوصف: | Background: Platinum-based neoadjuvant chemotherapy (NAC) increases the survival of patients with organ-confined urothelial bladder cancer (UBC). In retrospective studies, patients with basal/squamous (BASQ)-like tumors present with more advanced disease and have worse prognosis. Transcriptomics-defined tumor subtypes are associated with response to NAC. Aim: To investigate whether immunohistochemical (IHC) subtyping predicts NAC response. Methods: Patients with muscle-invasive UBC having received platinum-based NAC were identified. Tissue microarrays were used to type tumors for KRT5/6, KRT14, GATA3, and FOXA1. Outcomes: progression-free survival and disease-specific survival; univariable and multivariate Cox regression models were applied. Results: We found a very high concordance between mRNA and protein expression. Using IHC-based hierarchical clustering, we classified 126 tumors in three subgroups: BASQ-like (FOXA1/GATA3 low; KRT5/6/14 high), Luminal-like (FOXA1/GATA3 high; KRT5/6/14 low), and mixed-cluster (FOXA1/GATA3 high; KRT5/6 high; KRT14 low). Applying multivariable analyses, patients with BASQ-like tumors were more likely to achieve a pathological response to NAC (OR 3.96; p = 0.017). The clinical benefit appeared reflected in the lack of significant survival differences between patients with BASQ-like and luminal tumors. Conclusions: Patients with BASQ-like tumors—identified through simple and robust IHC—have a higher likelihood of undergoing a pathological complete response to NAC. Prospective validation is required. ; Asociación Española Contra el Cáncer ; Fondo de Investigaciones Sanitarias (FIS) ; Instituto de Salud Carlos III ; Red Temática de Investigación Cooperativa en Cáncer, Spain ; Depto. de Estadística y Ciencia de los Datos ; Fac. de Estudios Estadísticos ; TRUE ; pub |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6694 |
| العلاقة: | PI18/01347and (#, # to NM and FXR). The funders had no role in the study design, data collection, management, or analysis and interpretation of the data.; RD12/0036/0034; RD12/0036/0050; https://hdl.handle.net/20.500.14352/96685Test; https://doi.org/10.3390/cancers12071784Test; https://www.mdpi.com/journal/cancersTest |
| DOI: | 10.3390/cancers12071784 |
| الإتاحة: | https://doi.org/20.500.14352/96685Test https://doi.org/10.3390/cancers12071784Test https://hdl.handle.net/20.500.14352/96685Test https://www.mdpi.com/journal/cancersTest |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.17B3BF3B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726694 |
|---|---|
| DOI: | 10.3390/cancers12071784 |